EphA4-ADAM10 Interplay Patterns the Cochlear Sensory Epithelium through Local Disruption of Adherens Junctions

• Published in: iScience Vol. 11; pp. 246 - 257
• Main Authors: Defourny, Jean, Peuckert, Christiane, Kullander, Klas, Malgrange, Brigitte
• Format: Journal Article Web Resource
• Language: English
• Published: United States Elsevier Inc 25.01.2019; Elsevier
• Subjects: Biochemistry, biophysics & molecular biology; Biochimie, biophysique & biologie moléculaire; Cell Biology; Developmental Biology; Life sciences; Physiology; Sciences du vivant; Developmental Biology; Physiology; Cell Biology

The cochlear sensory epithelium contains a functionally important triangular fluid-filled space between adjacent pillar cells referred to as the tunnel of Corti. However, the molecular mechanisms leading to local cell-cell separation during development remain elusive. Here we show that EphA4 associa...