Prognostic impact of low allelic ratio FLT3-ITD and NPM1 mutation in acute myeloid leukemia

• Published in: Blood advances Vol. 2; no. 20; pp. 2744 - 2754
• Main Authors: Sakaguchi, Masahiro, Yamaguchi, Hiroki, Najima, Yuho, Usuki, Kensuke, Ueki, Toshimitsu, Oh, Iekuni, Mori, Sinichiro, Kawata, Eri, Uoshima, Nobuhiko, Kobayashi, Yutaka, Kako, Shinichi, Tajika, Kenji, Gomi, Seiji, Shono, Katsuhiro, Kayamori, Kensuke, Hagihara, Masao, Kanda, Junya, Uchiyama, Hitoji, Kuroda, Junya, Uchida, Naoyuki, Kubota, Yasushi, Kimura, Shinya, Kurosawa, Saiko, Nakajima, Nana, Marumo, Atsushi, Omori, Ikuko, Fujiwara, Yusuke, Yui, Shunsuke, Wakita, Satoshi, Arai, Kunihito, Kitano, Tomoaki, Kakihana, Kazuhiko, Kanda, Yoshinobu, Ohashi, Kazuteru, Fukuda, Takahiro, Inokuchi, Koiti
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 23.10.2018; American Society of Hematology
• Subjects: Myeloid Neoplasia

In the opinion of the European LeukemiaNet (ELN), nucleophosmin member 1 gene mutation (NPM1 mut)–positive acute myeloid leukemia (AML) with an fms-like kinase 3-internal tandem duplication (FLT3-ITD) allele ratio (AR) <0.5 (low AR) has a favorable prognosis, and allogeneic hematopoietic stem cel...