Clinical and prognostic significance of serum transforming growth factor-beta1 levels in patients with pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year survival rate of 5%. Biomarkers for the early detection of pancreatic cancer are urgently needed. Transforming growth factor-beta1 (TGF-β1) is elevated in the tissues and plasma of patients with PDAC. However, no studies systemically report p...

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Published inBrazilian journal of medical and biological research Vol. 49; no. 8
Main Authors Zhao, J., Liang, Y., Yin, Q., Liu, S., Wang, Q., Tang, Y., Cao, C.
Format Journal Article
LanguageEnglish
Published Brazil Associacao Brasileira de Divulgacao Cientifica (ABDC) 25.07.2016
Associação Brasileira de Divulgação Científica
Subjects
Adenocarcinoma
BIOLOGY
Biomarkers, Tumor - blood
Carcinoma, Pancreatic Ductal - blood
Carcinoma, Pancreatic Ductal - diagnosis
Carcinoma, Pancreatic Ductal - secondary
Clinical Investigation
Humans
Kaplan-Meier Estimate
Marker
MEDICINE, RESEARCH & EXPERIMENTAL
Pancreatic ductal adenocarcinoma
Pancreatic Neoplasms - blood
Pancreatic Neoplasms - diagnosis
Pancreatic Neoplasms - secondary
Prognosis
Retrospective Studies
Sensitivity and Specificity
TGF-β1
Transforming Growth Factor beta1 - blood
Transforming growth factors
TGF-β1
Pancreatic ductal adenocarcinoma
Marker
Online AccessGet full text

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Abstract Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year survival rate of 5%. Biomarkers for the early detection of pancreatic cancer are urgently needed. Transforming growth factor-beta1 (TGF-β1) is elevated in the tissues and plasma of patients with PDAC. However, no studies systemically report prognostic significance of plasma TGF-β1 levels in PDAC. In the present study, we assessed the prognostic significance of serum TGF-β levels in patients with PDAC. TGF-β levels were determined in serum from 146 PDAC patients, and 58 patients with benign pancreatic conditions. Regression models were used to correlate TGF-β levels to gender, age, stage, class, and metastasis. Survival analyses were performed using multivariate Cox models. Serum levels of TGF-β1 distinguished PDAC from benign pancreatic conditions (P<0.001) and healthy control subjects (P<0.001). Serum levels of TGF-β also distinguished tumor stage (P=0.002) and lymph node metastasis (P=0.001). High serum levels of TGF-β1 were significantly correlated with reduced patient survival. Multivariate analysis revealed that TGF-β1, lymph node metastasis and tumor stage were independent factors for PDAC survival. Our results indicate that serum TGF-β1 may be used as a potential prognostic marker for PDAC.
AbstractList Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year survival rate of 5%. Biomarkers for the early detection of pancreatic cancer are urgently needed. Transforming growth factor-beta1 (TGF-β1) is elevated in the tissues and plasma of patients with PDAC. However, no studies systemically report prognostic significance of plasma TGF-β1 levels in PDAC. In the present study, we assessed the prognostic significance of serum TGF-β levels in patients with PDAC. TGF-β levels were determined in serum from 146 PDAC patients, and 58 patients with benign pancreatic conditions. Regression models were used to correlate TGF-β levels to gender, age, stage, class, and metastasis. Survival analyses were performed using multivariate Cox models. Serum levels of TGF-β1 distinguished PDAC from benign pancreatic conditions (P<0.001) and healthy control subjects (P<0.001). Serum levels of TGF-β also distinguished tumor stage (P=0.002) and lymph node metastasis (P=0.001). High serum levels of TGF-β1 were significantly correlated with reduced patient survival. Multivariate analysis revealed that TGF-β1, lymph node metastasis and tumor stage were independent factors for PDAC survival. Our results indicate that serum TGF-β1 may be used as a potential prognostic marker for PDAC.Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year survival rate of 5%. Biomarkers for the early detection of pancreatic cancer are urgently needed. Transforming growth factor-beta1 (TGF-β1) is elevated in the tissues and plasma of patients with PDAC. However, no studies systemically report prognostic significance of plasma TGF-β1 levels in PDAC. In the present study, we assessed the prognostic significance of serum TGF-β levels in patients with PDAC. TGF-β levels were determined in serum from 146 PDAC patients, and 58 patients with benign pancreatic conditions. Regression models were used to correlate TGF-β levels to gender, age, stage, class, and metastasis. Survival analyses were performed using multivariate Cox models. Serum levels of TGF-β1 distinguished PDAC from benign pancreatic conditions (P<0.001) and healthy control subjects (P<0.001). Serum levels of TGF-β also distinguished tumor stage (P=0.002) and lymph node metastasis (P=0.001). High serum levels of TGF-β1 were significantly correlated with reduced patient survival. Multivariate analysis revealed that TGF-β1, lymph node metastasis and tumor stage were independent factors for PDAC survival. Our results indicate that serum TGF-β1 may be used as a potential prognostic marker for PDAC.
Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year survival rate of 5%. Biomarkers for the early detection of pancreatic cancer are urgently needed. Transforming growth factor-beta1 (TGF-β1) is elevated in the tissues and plasma of patients with PDAC. However, no studies systemically report prognostic significance of plasma TGF-β1 levels in PDAC. In the present study, we assessed the prognostic significance of serum TGF-β levels in patients with PDAC. TGF-β levels were determined in serum from 146 PDAC patients, and 58 patients with benign pancreatic conditions. Regression models were used to correlate TGF-β levels to gender, age, stage, class, and metastasis. Survival analyses were performed using multivariate Cox models. Serum levels of TGF-β1 distinguished PDAC from benign pancreatic conditions (P<0.001) and healthy control subjects (P<0.001). Serum levels of TGF-β also distinguished tumor stage (P=0.002) and lymph node metastasis (P=0.001). High serum levels of TGF-β1 were significantly correlated with reduced patient survival. Multivariate analysis revealed that TGF-β1, lymph node metastasis and tumor stage were independent factors for PDAC survival. Our results indicate that serum TGF-β1 may be used as a potential prognostic marker for PDAC.
Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year survival rate of 5%. Biomarkers for the early detection of pancreatic cancer are urgently needed. Transforming growth factor-beta1 (TGF-[beta]1) is elevated in the tissues and plasma of patients with PDAC. However, no studies systemically report prognostic significance of plasma TGF-[beta]1 levels in PDAC. In the present study, we assessed the prognostic significance of serum TGF-[beta] levels in patients with PDAC. TGF-[beta] levels were determined in serum from 146 PDAC patients, and 58 patients with benign pancreatic conditions. Regression models were used to correlate TGF-[beta] levels to gender, age, stage, class, and metastasis. Survival analyses were performed using multivariate Cox models. Serum levels of TGF-[beta]1 distinguished PDAC from benign pancreatic conditions (P<0.001) and healthy control subjects (P<0.001). Serum levels of TGF-[beta] also distinguished tumor stage (P=0.002) and lymph node metastasis (P=0.001). High serum levels of TGF-[beta]1 were significantly correlated with reduced patient survival. Multivariate analysis revealed that TGF-[beta]1, lymph node metastasis and tumor stage were independent factors for PDAC survival. Our results indicate that serum TGF-[beta]1 may be used as a potential prognostic marker for PDAC.
Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year survival rate of 5%. Biomarkers for the early detection of pancreatic cancer are urgently needed. Transforming growth factor-beta1 (TGF-[beta]1) is elevated in the tissues and plasma of patients with PDAC. However, no studies systemically report prognostic significance of plasma TGF-[beta]1 levels in PDAC. In the present study, we assessed the prognostic significance of serum TGF-[beta] levels in patients with PDAC. TGF-[beta] levels were determined in serum from 146 PDAC patients, and 58 patients with benign pancreatic conditions. Regression models were used to correlate TGF-[beta] levels to gender, age, stage, class, and metastasis. Survival analyses were performed using multivariate Cox models. Serum levels of TGF-[beta]1 distinguished PDAC from benign pancreatic conditions (P<0.001) and healthy control subjects (P<0.001). Serum levels of TGF-[beta] also distinguished tumor stage (P=0.002) and lymph node metastasis (P=0.001). High serum levels of TGF-[beta]1 were significantly correlated with reduced patient survival. Multivariate analysis revealed that TGF-[beta]1, lymph node metastasis and tumor stage were independent factors for PDAC survival. Our results indicate that serum TGF-[beta]1 may be used as a potential prognostic marker for PDAC. Key words: Pancreatic ductal adenocarcinoma; Marker; TGF-[beta]1
Audience Academic
Author Wang, Q.
Yin, Q.
Cao, C.
Liang, Y.
Tang, Y.
Zhao, J.
Liu, S.
AuthorAffiliation Jinan Central Hospital
People's Hospital of Weifang
People's Hospital of Zhangqiu
People's Hospital of Rizhao
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Keywords TGF-β1
Pancreatic ductal adenocarcinoma
Marker
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Snippet Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year survival rate of 5%. Biomarkers for the early detection of pancreatic cancer are urgently needed....
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SubjectTerms Adenocarcinoma
BIOLOGY
Biomarkers, Tumor - blood
Carcinoma, Pancreatic Ductal - blood
Carcinoma, Pancreatic Ductal - diagnosis
Carcinoma, Pancreatic Ductal - secondary
Clinical Investigation
Humans
Kaplan-Meier Estimate
Marker
MEDICINE, RESEARCH & EXPERIMENTAL
Pancreatic ductal adenocarcinoma
Pancreatic Neoplasms - blood
Pancreatic Neoplasms - diagnosis
Pancreatic Neoplasms - secondary
Prognosis
Retrospective Studies
Sensitivity and Specificity
TGF-β1
Transforming Growth Factor beta1 - blood
Transforming growth factors
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Title Clinical and prognostic significance of serum transforming growth factor-beta1 levels in patients with pancreatic ductal adenocarcinoma
URI https://www.ncbi.nlm.nih.gov/pubmed/27464025
https://www.proquest.com/docview/1807875236
https://pubmed.ncbi.nlm.nih.gov/PMC4964897
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