Mannose receptor interacts with Fc receptors and is critical for the development of crescentic glomerulonephritis in mice

• Published in: The Journal of clinical investigation Vol. 120; no. 5; pp. 1469 - 1478
• Main Authors: Chavele, Konstantia-Maria, Martinez-Pomares, Luisa, Domin, Jan, Pemberton, Samantha, Haslam, Stuart M., Dell, Anne, Cook, H. Terence, Pusey, Charles D., Gordon, Siamon, Salama, Alan D.
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.05.2010
• Subjects: Animals; Antigens; Apoptosis; Biomedical research; Care and treatment; Creatinine; Cytokines; Dengue fever; Development and progression; Female; Gene Expression Regulation; Glomerulonephritis; Glomerulonephritis - metabolism; Histology; Inflammation; Kidney diseases; Lectins, C-Type - metabolism; Lymphocytes; Macrophages - metabolism; Male; Mannose Receptor; Mannose receptors; Mannose-Binding Lectins - metabolism; Mesangial Cells - metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Biological; Oxygen - metabolism; Phagocytosis; Phosphorylation; Properties; Receptors, Cell Surface - metabolism; Receptors, Fc - metabolism; T-Lymphocytes - metabolism; United Kingdom

Crescentic glomerulonephritis (CGN), which frequently results in acute and chronic kidney disease, is characterized by and dependent on glomerular infiltration by macrophages. The mannose receptor (MR) is a pattern recognition receptor implicated in the uptake of endogenous and microbial ligands by...