Protective efficacy of six recombinant proteins as vaccine candidates against Echinococcus granulosus in dogs

• Published in: PLoS neglected tropical diseases Vol. 17; no. 10; p. e0011709
• Main Authors: Shao, Guoqing, Hua, Ruiqi, Song, Hongyu, Chen, Yanxin, Zhu, Xiaowei, Hou, Wei, Li, Shengqiong, Yang, Aiguo, Yang, Guangyou
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 01.10.2023; Public Library of Science (PLoS)
• Subjects: Adenylate kinase; Antigens; Biology and Life Sciences; Body length; Calcium; Calcium-binding protein; Cysts; Disease transmission; Dogs; E coli; Echinococcosis; Echinococcus granulosus; Effectiveness; Enzyme-linked immunosorbent assay; Enzymes; Fatty acid-binding protein; Fatty acids; Health aspects; Immunoglobulin G; Infections; Kinases; Laboratory animals; Medicine and Health Sciences; Parasites; Parasitic diseases; Praziquantel; Protein binding; Proteins; Recombinant proteins; Recombinants; Sheep; Triose-phosphate isomerase; Vaccination; Vaccines; China; Beijing China; United States > US

Background Cystic echinococcosis (CE) is caused by the infection of Echinococcus granulosus sensu lato (E. granulosus s.l.), one of the most harmful zoonotic helminths worldwide. Infected dogs are the major source of CE transmission. While praziquantel-based deworming is a main measure employed to c...