Overdose pattern and outcome in paracetamol‐induced acute severe hepatotoxicity

• Published in: British journal of clinical pharmacology Vol. 71; no. 2; pp. 273 - 282
• Main Authors: Craig, Darren G. N., Bates, Caroline M., Davidson, Janice S., Martin, Kirsty G., Hayes, Peter C., Simpson, Kenneth J.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.02.2011; Blackwell; Blackwell Science Inc
• Subjects: Abuse; Acetaminophen; Acetaminophen - poisoning; acute; Adult; Aged; Alanine transaminase; Analgesics; Analgesics, Non-Narcotic - poisoning; Biological and medical sciences; Contraindications; Cysteine; Data processing; Drug Overdose; drug‐induced liver injury; Epidemiologic Methods; Ethanol; Female; Gastroenterology. Liver. Pancreas. Abdomen; hepatic encephalopathy; hepatotoxicity; Humans; Injuries; Liver diseases; liver failure; Liver Failure, Acute - chemically induced; Liver Failure, Acute - diagnosis; Liver Failure, Acute - surgery; Liver Transplantation; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Middle Aged; Mortality; Multivariate analysis; Other diseases. Semiology; Overdose; paracetamol; Pharmacoepidemiology; Pharmacology. Drug treatments; Prognosis; Risk groups; Suicide, Attempted; Survival; Drug; drug-induced liver injury; Prognosis; Digestive system; Toxicity; Acute; Antimigrainous agent; Liver; Overdosing; Hepatic disease; Liver failure; Paracetamol; Analgesic; Antipyretic; Digestive diseases; Hepatic encephalopathy; Liver transplantation

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Paracetamol hepatotoxicity is the commonest cause of acute liver failure (ALF) in the UK. • Conflicting data exist regarding the impact of overdose pattern upon subsequent mortality or need for emergency liver transplantation. WHAT THIS STUDY ADDS • Uninten...