Biosynthesis of astaxanthin in tobacco leaves by transplastomic engineering
Summary The natural pigment astaxanthin has attracted much attention because of its beneficial effects on human health, despite its expensive market price. In order to produce astaxanthin, transgenic plants have so far been generated through conventional genetic engineering of Agrobacterium‐mediated...
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| Published in | The Plant journal : for cell and molecular biology Vol. 55; no. 5; pp. 857 - 868 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Publishing Ltd
01.09.2008
Blackwell Science |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Summary
The natural pigment astaxanthin has attracted much attention because of its beneficial effects on human health, despite its expensive market price. In order to produce astaxanthin, transgenic plants have so far been generated through conventional genetic engineering of Agrobacterium‐mediated gene transfer. The results of trials have revealed that the method is far from practicable because of low yields, i.e. instead of astaxanthin, large quantities of the astaxanthin intermediates, including ketocarotenoids, accumulated in the transgenic plants. In the present study, we have overcome this problem, and have succeeded in producing more than 0.5% (dry weight) astaxanthin (more than 70% of total caroteniods) in tobacco leaves, which turns their green color to reddish brown, by expressing both genes encoding CrtW (β‐carotene ketolase) and CrtZ (β‐carotene hydroxylase) from a marine bacterium Brevundimonas sp., strain SD212, in the chloroplasts. Moreover, the total carotenoid content in the transplastomic tobacco plants was 2.1‐fold higher than that of wild‐type tobacco. The tobacco transformants also synthesized a novel carotenoid 4‐ketoantheraxanthin. There was no significant difference in the size of the aerial part of the plant between the transformants and wild‐type plants at the final stage of their growth. The photosynthesis rate of the transformants was also found to be similar to that of wild‐type plants under ambient CO2 concentrations of 1500 μmol photons m−2 s−1 light intensity. |
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| AbstractList | The natural pigment astaxanthin has attracted much attention because of its beneficial effects on human health, despite its expensive market price. In order to produce astaxanthin, transgenic plants have so far been generated through conventional genetic engineering of
Agrobacterium
‐mediated gene transfer. The results of trials have revealed that the method is far from practicable because of low yields, i.e. instead of astaxanthin, large quantities of the astaxanthin intermediates, including ketocarotenoids, accumulated in the transgenic plants. In the present study, we have overcome this problem, and have succeeded in producing more than 0.5% (dry weight) astaxanthin (more than 70% of total caroteniods) in tobacco leaves, which turns their green color to reddish brown, by expressing both genes encoding CrtW (β‐carotene ketolase) and CrtZ (β‐carotene hydroxylase) from a marine bacterium
Brevundimonas
sp., strain SD212, in the chloroplasts. Moreover, the total carotenoid content in the transplastomic tobacco plants was 2.1‐fold higher than that of wild‐type tobacco. The tobacco transformants also synthesized a novel carotenoid 4‐ketoantheraxanthin. There was no significant difference in the size of the aerial part of the plant between the transformants and wild‐type plants at the final stage of their growth. The photosynthesis rate of the transformants was also found to be similar to that of wild‐type plants under ambient CO
2
concentrations of 1500 μmol photons m
−2
s
−1
light intensity. The natural pigment astaxanthin has attracted much attention because of its beneficial effects on human health, despite its expensive market price. In order to produce astaxanthin, transgenic plants have so far been generated through conventional genetic engineering of Agrobacterium-mediated gene transfer. The results of trials have revealed that the method is far from practicable because of low yields, i.e. instead of astaxanthin, large quantities of the astaxanthin intermediates, including ketocarotenoids, accumulated in the transgenic plants. In the present study, we have overcome this problem, and have succeeded in producing more than 0.5% (dry weight) astaxanthin (more than 70% of total caroteniods) in tobacco leaves, which turns their green color to reddish brown, by expressing both genes encoding CrtW (beta-carotene ketolase) and CrtZ (beta-carotene hydroxylase) from a marine bacterium Brevundimonas sp., strain SD212, in the chloroplasts. Moreover, the total carotenoid content in the transplastomic tobacco plants was 2.1-fold higher than that of wild-type tobacco. The tobacco transformants also synthesized a novel carotenoid 4-ketoantheraxanthin. There was no significant difference in the size of the aerial part of the plant between the transformants and wild-type plants at the final stage of their growth. The photosynthesis rate of the transformants was also found to be similar to that of wild-type plants under ambient CO2 concentrations of 1500 micromol photons m(-2) s(-1) light intensity.SUMMARYThe natural pigment astaxanthin has attracted much attention because of its beneficial effects on human health, despite its expensive market price. In order to produce astaxanthin, transgenic plants have so far been generated through conventional genetic engineering of Agrobacterium-mediated gene transfer. The results of trials have revealed that the method is far from practicable because of low yields, i.e. instead of astaxanthin, large quantities of the astaxanthin intermediates, including ketocarotenoids, accumulated in the transgenic plants. In the present study, we have overcome this problem, and have succeeded in producing more than 0.5% (dry weight) astaxanthin (more than 70% of total caroteniods) in tobacco leaves, which turns their green color to reddish brown, by expressing both genes encoding CrtW (beta-carotene ketolase) and CrtZ (beta-carotene hydroxylase) from a marine bacterium Brevundimonas sp., strain SD212, in the chloroplasts. Moreover, the total carotenoid content in the transplastomic tobacco plants was 2.1-fold higher than that of wild-type tobacco. The tobacco transformants also synthesized a novel carotenoid 4-ketoantheraxanthin. There was no significant difference in the size of the aerial part of the plant between the transformants and wild-type plants at the final stage of their growth. The photosynthesis rate of the transformants was also found to be similar to that of wild-type plants under ambient CO2 concentrations of 1500 micromol photons m(-2) s(-1) light intensity. The natural pigment astaxanthin has attracted much attention because of its beneficial effects on human health, despite its expensive market price. In order to produce astaxanthin, transgenic plants have so far been generated through conventional genetic engineering of Agrobacterium-mediated gene transfer. The results of trials have revealed that the method is far from practicable because of low yields, i.e. instead of astaxanthin, large quantities of the astaxanthin intermediates, including ketocarotenoids, accumulated in the transgenic plants. In the present study, we have overcome this problem, and have succeeded in producing more than 0.5% (dry weight) astaxanthin (more than 70% of total caroteniods) in tobacco leaves, which turns their green color to reddish brown, by expressing both genes encoding CrtW ([beta]-carotene ketolase) and CrtZ ([beta]-carotene hydroxylase) from a marine bacterium Brevundimonas sp., strain SD212, in the chloroplasts. Moreover, the total carotenoid content in the transplastomic tobacco plants was 2.1-fold higher than that of wild-type tobacco. The tobacco transformants also synthesized a novel carotenoid 4-ketoantheraxanthin. There was no significant difference in the size of the aerial part of the plant between the transformants and wild-type plants at the final stage of their growth. The photosynthesis rate of the transformants was also found to be similar to that of wild-type plants under ambient CO2 concentrations of 1500 mmol photons m-2 s-1 light intensity. [PUBLICATION ABSTRACT] The natural pigment astaxanthin has attracted much attention because of its beneficial effects on human health, despite its expensive market price. In order to produce astaxanthin, transgenic plants have so far been generated through conventional genetic engineering of Agrobacterium-mediated gene transfer. The results of trials have revealed that the method is far from practicable because of low yields, i.e. instead of astaxanthin, large quantities of the astaxanthin intermediates, including ketocarotenoids, accumulated in the transgenic plants. In the present study, we have overcome this problem, and have succeeded in producing more than 0.5% (dry weight) astaxanthin (more than 70% of total caroteniods) in tobacco leaves, which turns their green color to reddish brown, by expressing both genes encoding CrtW (β-carotene ketolase) and CrtZ (β-carotene hydroxylase) from a marine bacterium Brevundimonas sp., strain SD212, in the chloroplasts. Moreover, the total carotenoid content in the transplastomic tobacco plants was 2.1-fold higher than that of wild-type tobacco. The tobacco transformants also synthesized a novel carotenoid 4-ketoantheraxanthin. There was no significant difference in the size of the aerial part of the plant between the transformants and wild-type plants at the final stage of their growth. The photosynthesis rate of the transformants was also found to be similar to that of wild-type plants under ambient CO₂ concentrations of 1500 μmol photons m⁻² s⁻¹ light intensity. The natural pigment astaxanthin has attracted much attention because of its beneficial effects on human health, despite its expensive market price. In order to produce astaxanthin, transgenic plants have so far been generated through conventional genetic engineering of Agrobacterium-mediated gene transfer. The results of trials have revealed that the method is far from practicable because of low yields, i.e. instead of astaxanthin, large quantities of the astaxanthin intermediates, including ketocarotenoids, accumulated in the transgenic plants. In the present study, we have overcome this problem, and have succeeded in producing more than 0.5% (dry weight) astaxanthin (more than 70% of total caroteniods) in tobacco leaves, which turns their green color to reddish brown, by expressing both genes encoding CrtW (b-carotene ketolase) and CrtZ (b-carotene hydroxylase) from a marine bacterium Brevundimonas sp., strain SD212, in the chloroplasts. Moreover, the total carotenoid content in the transplastomic tobacco plants was 2.1-fold higher than that of wild-type tobacco. The tobacco transformants also synthesized a novel carotenoid 4-ketoantheraxanthin. There was no significant difference in the size of the aerial part of the plant between the transformants and wild-type plants at the final stage of their growth. The photosynthesis rate of the transformants was also found to be similar to that of wild-type plants under ambient CO sub(2) concentrations of 1500kmolphotonsm super(-2)&thi nsp; s super(-1) light intensity. The natural pigment astaxanthin has attracted much attention because of its beneficial effects on human health, despite its expensive market price. In order to produce astaxanthin, transgenic plants have so far been generated through conventional genetic engineering of Agrobacterium-mediated gene transfer. The results of trials have revealed that the method is far from practicable because of low yields, i.e. instead of astaxanthin, large quantities of the astaxanthin intermediates, including ketocarotenoids, accumulated in the transgenic plants. In the present study, we have overcome this problem, and have succeeded in producing more than 0.5% (dry weight) astaxanthin (more than 70% of total caroteniods) in tobacco leaves, which turns their green color to reddish brown, by expressing both genes encoding CrtW (beta-carotene ketolase) and CrtZ (beta-carotene hydroxylase) from a marine bacterium Brevundimonas sp., strain SD212, in the chloroplasts. Moreover, the total carotenoid content in the transplastomic tobacco plants was 2.1-fold higher than that of wild-type tobacco. The tobacco transformants also synthesized a novel carotenoid 4-ketoantheraxanthin. There was no significant difference in the size of the aerial part of the plant between the transformants and wild-type plants at the final stage of their growth. The photosynthesis rate of the transformants was also found to be similar to that of wild-type plants under ambient CO2 concentrations of 1500 micromol photons m(-2) s(-1) light intensity. Summary The natural pigment astaxanthin has attracted much attention because of its beneficial effects on human health, despite its expensive market price. In order to produce astaxanthin, transgenic plants have so far been generated through conventional genetic engineering of Agrobacterium‐mediated gene transfer. The results of trials have revealed that the method is far from practicable because of low yields, i.e. instead of astaxanthin, large quantities of the astaxanthin intermediates, including ketocarotenoids, accumulated in the transgenic plants. In the present study, we have overcome this problem, and have succeeded in producing more than 0.5% (dry weight) astaxanthin (more than 70% of total caroteniods) in tobacco leaves, which turns their green color to reddish brown, by expressing both genes encoding CrtW (β‐carotene ketolase) and CrtZ (β‐carotene hydroxylase) from a marine bacterium Brevundimonas sp., strain SD212, in the chloroplasts. Moreover, the total carotenoid content in the transplastomic tobacco plants was 2.1‐fold higher than that of wild‐type tobacco. The tobacco transformants also synthesized a novel carotenoid 4‐ketoantheraxanthin. There was no significant difference in the size of the aerial part of the plant between the transformants and wild‐type plants at the final stage of their growth. The photosynthesis rate of the transformants was also found to be similar to that of wild‐type plants under ambient CO2 concentrations of 1500 μmol photons m−2 s−1 light intensity. |
| Author | Yoshimura, Satomi Tomizawa, Ken‐Ichi Miyake, Chikahiro Shindo, Kazutoshi Hasunuma, Tomohisa Misawa, Norihiko Miyazawa, Shin‐Ichi Shinzaki, Yuki Choi, Seon‐Kang |
| Author_xml | – sequence: 1 givenname: Tomohisa surname: Hasunuma fullname: Hasunuma, Tomohisa – sequence: 2 givenname: Shin‐Ichi surname: Miyazawa fullname: Miyazawa, Shin‐Ichi – sequence: 3 givenname: Satomi surname: Yoshimura fullname: Yoshimura, Satomi – sequence: 4 givenname: Yuki surname: Shinzaki fullname: Shinzaki, Yuki – sequence: 5 givenname: Ken‐Ichi surname: Tomizawa fullname: Tomizawa, Ken‐Ichi – sequence: 6 givenname: Kazutoshi surname: Shindo fullname: Shindo, Kazutoshi – sequence: 7 givenname: Seon‐Kang surname: Choi fullname: Choi, Seon‐Kang – sequence: 8 givenname: Norihiko surname: Misawa fullname: Misawa, Norihiko – sequence: 9 givenname: Chikahiro surname: Miyake fullname: Miyake, Chikahiro |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20608725$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/18494855$$D View this record in MEDLINE/PubMed |
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| Copyright | 2008 The Authors. Journal compilation © 2008 Blackwell Publishing Ltd 2008 INIST-CNRS Journal compilation © 2008 Blackwell Publishing Ltd and the Society for Experimental Biology |
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| Keywords | Enzyme Growth Hydroxylase Carbon dioxide Biosynthesis Plant leaf Plastid Nicotiana tabacum Genetic transfer astaxanthin plastid transformation Gene Dicotyledones Angiospermae Above ground plant part Spermatophyta Genetic engineering Transgenic plant Oxidoreductases Solanaceae metabolic engineering Photosynthesis Carotenoid Chloroplast |
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| Notes | Present address: Department of Biological and Environmental Science, Faculty of Agriculture, Kobe University, 1‐1 Rokkodai‐cho, Nada‐ku, Kobe, 657‐8501, Japan. Present address: Department of Chemical Science and Engineering, Faculty of Engineering, Kobe University, 1‐1 Rokkodai‐cho, Nada‐ku, Kobe, 657‐8501, Japan. SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 |
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| PublicationTitle | The Plant journal : for cell and molecular biology |
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| References | 2007; 145 2006; 72 2007; 282 2006; 57 1997; 272 2000; 24 1991; 11 1999; 270 1987; 6 2000; 7 2006; 15 2005; 579 2005; 41 2006; 8 2007 1962; 15 2002; 4 1995 2002; 418 2004 1993; 90 1995; 177 2007; 75 1993; 4 1995; 8 2005; 46 2001; 276 1980; 149 2004; 55 1982; 48 2000; 18 2004; 136 2005; 221 2004; 39 2000; 545 1991; 63 1995; 23 2006; 47 2008; 49 2001; 19 2003; 24 2005; 7 1985; 51 1994; 15 2007; 2 2005; 71 2003; 21 e_1_2_6_51_1 e_1_2_6_32_1 e_1_2_6_30_1 Tatsuzawa H. (e_1_2_6_47_1) 2000; 545 e_1_2_6_19_1 e_1_2_6_13_1 e_1_2_6_36_1 e_1_2_6_11_1 e_1_2_6_34_1 e_1_2_6_17_1 e_1_2_6_15_1 e_1_2_6_38_1 e_1_2_6_20_1 e_1_2_6_41_1 e_1_2_6_9_1 e_1_2_6_5_1 e_1_2_6_7_1 e_1_2_6_24_1 e_1_2_6_49_1 e_1_2_6_3_1 e_1_2_6_22_1 e_1_2_6_28_1 e_1_2_6_45_1 e_1_2_6_26_1 e_1_2_6_10_1 e_1_2_6_31_1 e_1_2_6_50_1 e_1_2_6_14_1 e_1_2_6_35_1 e_1_2_6_12_1 e_1_2_6_33_1 e_1_2_6_18_1 e_1_2_6_39_1 e_1_2_6_16_1 e_1_2_6_37_1 e_1_2_6_42_1 e_1_2_6_21_1 e_1_2_6_40_1 Sokal R.R. (e_1_2_6_43_1) 1995 e_1_2_6_8_1 e_1_2_6_4_1 e_1_2_6_6_1 e_1_2_6_25_1 e_1_2_6_48_1 e_1_2_6_23_1 e_1_2_6_2_1 e_1_2_6_29_1 e_1_2_6_44_1 e_1_2_6_27_1 e_1_2_6_46_1 |
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The natural pigment astaxanthin has attracted much attention because of its beneficial effects on human health, despite its expensive market price. In... The natural pigment astaxanthin has attracted much attention because of its beneficial effects on human health, despite its expensive market price. In order to... |
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| SubjectTerms | aerial parts astaxanthin Bacteria beta-carotene Biological and medical sciences Biosynthesis Botany Brevundimonas Carbon dioxide carotenoid Caulobacteraceae Caulobacteraceae - genetics chloroplasts color developmental stages DNA, Plant DNA, Plant - genetics engineering Fundamental and applied biological sciences. Psychology Gene expression gene transfer genes Genes, Bacterial Genetic Engineering genetics Genome, Chloroplast human health Leaves Light intensity market prices metabolic engineering Metabolism Metabolism. Physicochemical requirements Nicotiana - genetics Nicotiana - metabolism Nicotiana tabacum Nitrogen Nitrogen - metabolism Oxygenases Oxygenases - genetics photons Photosynthesis Plant Leaves Plant Leaves - genetics Plant Leaves - metabolism Plant physiology and development Plants, Genetically Modified Plants, Genetically Modified - genetics Plants, Genetically Modified - metabolism plastid transformation Plastids Plastids - genetics Ribulose-Bisphosphate Carboxylase Ribulose-Bisphosphate Carboxylase - metabolism RNA, Plant RNA, Plant - genetics Tobacco Transgenic plants Xanthophylls Xanthophylls - biosynthesis |
| Title | Biosynthesis of astaxanthin in tobacco leaves by transplastomic engineering |
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