Blood monocyte activation in rheumatoid arthritis: increased monocyte adhesiveness, integrin expression, and cytokine release

• Published in: Clinical and experimental immunology Vol. 106; no. 1; pp. 13 - 19
• Main Authors: LIOTÉ, F., BOVAL‐BOIZARD, B., WEILL, D., KUNTZ, D., WAUTIER, J.‐L.
• Format: Journal Article
• Language: English
• Published: Oxford BSL Blackwell Science Ltd 01.10.1996; Blackwell; Blackwell Science Inc
• Subjects: Arthritis, Rheumatoid - immunology; Biological and medical sciences; cell adhesion; Cell Adhesion - immunology; Cell Adhesion Molecules - biosynthesis; Cells, Cultured; Cytokines - metabolism; Diseases of the osteoarticular system; Endothelium, Vascular - metabolism; Humans; Inflammatory joint diseases; integrins; Integrins - biosynthesis; Interleukin-1 - metabolism; Interleukin-6 - metabolism; Macrophage Activation - immunology; Medical sciences; monocyte; Monocytes - immunology; Monocytes - metabolism; Original; rheumatoid arthritis; Tumor Necrosis Factor-alpha - metabolism; VLA antigen; Human; Immunopathology; Synovitis; Monocyte; Diseases of the osteoarticular system; Cytokine; Cell adhesion molecule; Autoimmune disease; Interleukin 1β; Inflammatory joint disease; Adhesion; Endothelium; Interleukin 6; Chronic; Integrin; Synovial membrane; Immunological investigation; Rheumatoid arthritis; Tumor necrosis factor α

Infiltration of the synovium by mononuclear cells, namely lymphocytes and monocytes, is one of the main features of rheumatoid arthritis (RA) and is considered to be responsible for the development of the disease. In this study in 31 consecutive patients with RA, we investigated whether peripheral b...