替诺福韦酯治疗慢性乙型肝炎的最新进展

在众多核苷和核苷酸类药物（NAs）中，替诺福韦（TDF）以其强效、低耐药性及对多种 NAs治疗失败的慢性乙型肝炎（CHB）患者有效的特点脱颖而出，使其在临床HBV感染治疗中被广泛应用。介绍了TDF对CHB初治患者和经治患者的疗效，并分析了其对肝硬化患者治疗的效果，同时也对TDF治疗的安全性进行了评估。认为TDF耐药率低、安全性好，为目前CHB治疗的一线药物。...

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Bibliographic Details
Published in临床肝胆病杂志 Vol. 31; no. 4; pp. 599 - 602
Main Author 张悦 吕洋 李旭 高普均
Format Journal Article
LanguageChinese
Published 吉林大学第一医院 肝胆胰内科,长春,130021%吉林大学第一医院 放射线科,长春,130021 2015
Subjects
乙型
慢性
替诺福韦
治疗结果
综述
肝炎
肝炎,乙型,慢性
治疗结果
review
综述
tenofovir disoproxil fumarate
替诺福韦
hepatitis B,chronic
treatment outcome
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ISSN1001-5256
DOI10.3969/j.issn.1001-5256.2015.04.030

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Summary:在众多核苷和核苷酸类药物（NAs）中，替诺福韦（TDF）以其强效、低耐药性及对多种 NAs治疗失败的慢性乙型肝炎（CHB）患者有效的特点脱颖而出，使其在临床HBV感染治疗中被广泛应用。介绍了TDF对CHB初治患者和经治患者的疗效，并分析了其对肝硬化患者治疗的效果，同时也对TDF治疗的安全性进行了评估。认为TDF耐药率低、安全性好，为目前CHB治疗的一线药物。
Bibliography:There are 400 million individuals infected with chronic hepatitis B virus （HBV）all over the world.The management of chronic hepatitis B （CHB）has been improved markedly over the last decade,primarily due to the availability of oral nucleoside analogue （NA） therapy.Among the numerous NAs,tenofovir disoproxil fumarate （TDF）stands out for its high therapeutic efficacy,low drug resistance, and wide disease spectrum against several types of chronic CHB that can not be cured with NAs.Thus,TDF has been widely used for clinical treatment of chronic HBV infection.This paper describes the efficacy of TDF in nave and treated patients and analyzes its effect on cirrho-sis.Furthermore,the safety of TDF therapy is assessed.It is considered that TDF has low resistance rate and high safety,which provides a first-line drug for CHB treatment.
hepatitis B,chronic; tenofovir disoproxil fumarate; treatment outcome; review
ZHANG Yue,LYU Yang,LI Xu,et al（Department of Hepatology, The First Hospital of Jilin University, Changchun 1300
ISSN:1001-5256
DOI:10.3969/j.issn.1001-5256.2015.04.030