Circulating osteocalcin is increased in early-stage diabetes

• Published in: Diabetes Research and Clinical Practice Vol. 92; no. 2; pp. 181 - 186
• Main Authors: Aoki, Atsushi, Muneyuki, Takatoshi, Yoshida, Masashi, Munakata, Hiromi, Ishikawa, San-e, Sugawara, Hitoshi, Kawakami, Masanobu, Kakei, Masafumi
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.05.2011; Elsevier BV
• Subjects: Adult; Blood Glucose; Blood Glucose - metabolism; blood serum; bone formation; confidence interval; creatinine; diabetes; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - physiopathology; Endocrinology & Metabolism; fasting; Female; glucose; Glucose Intolerance; Glucose Intolerance - blood; Glucose Intolerance - physiopathology; glucose tolerance; Glucose Tolerance Test; glucose tolerance tests; Humans; Leptin; Leptin - blood; logit analysis; Male; men; Middle Aged; Obese; odds ratio; Osteocalcin; Osteocalcin - blood; Type 2 diabetes mellitus; women; Osteocalcin; Obese; Type 2 diabetes mellitus; Leptin

We aimed to examine whether circulating levels of osteocalcin, bone formation marker secreted from osteoblast, are changed in glucose-intolerant subjects without taking glucose lowering agent, because bone metabolism is reportedly related to glucose metabolism in animal and human studies. According...