The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice

• Published in: Nature communications Vol. 2; no. 1; p. 181
• Main Authors: Yamamoto, Masayuki, Komatsu, Masaaki, Tatsumi, Kanako, Yamamoto-Mukai, Harumi, Shimizu, Ritsuko, Waguri, Satoshi, Sou, Yu-Shin, Sakamoto, Ayako, Taya, Choji, Shitara, Hiroshi, Hara, Takahiko, Chung, Chin Ha, Tanaka, Keiji
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.02.2011; Nature Publishing Group
• Subjects: 631/136/232/1473; 631/337/458/582; 692/699/1541/13; Animals; Cell Differentiation - physiology; Cell Line; Colony-Forming Units Assay; DNA Primers - genetics; Erythroid Cells; Flow Cytometry; Hematopoiesis - physiology; Humanities and Social Sciences; Humans; Immunoblotting; Immunoprecipitation; Mice; Mice, Transgenic; multidisciplinary; Protein Processing, Post-Translational - physiology; Proteins - metabolism; Reverse Transcriptase Polymerase Chain Reaction; Science; Science (multidisciplinary); Ubiquitin-Activating Enzymes - genetics; Ubiquitin-Activating Enzymes - metabolism

Post-translational protein modifications are systems designed to expand restricted genomic information through functional conversion of target molecules. Ubiquitin-like post-translational modifiers regulate numerous cellular events through their covalent linkages to target protein(s) by an enzymatic...