Effect of prior vaccination on carriage rates of Streptococcus pneumoniae in older adults: A longitudinal surveillance study

• Published in: Vaccine Vol. 36; no. 29; pp. 4304 - 4310
• Main Authors: Branche, Angela R., Yang, Hongmei, Java, James, Holden-Wiltse, Jeanne, Topham, David J., Peasley, Michael, Frost, Michael R., Nahm, Moon H., Falsey, Ann R.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 05.07.2018; Elsevier Limited
• Subjects: Adults; agar; Age; Aged; Aged, 80 and over; Allergy and Immunology; autumn; blood; Cardiovascular disease; Carrier State - epidemiology; Children; Colonization; Coronary vessels; Culture; culture media; demographic statistics; Demographics; Demography; Deoxyribonucleic acid; DNA; elderly; Epidemiological Monitoring; Female; genes; Gentamicin; Glycerol; Humans; Immunization; Immunoassay; Incidence; Laboratories; Longitudinal Studies; Male; Molecular chains; monitoring; Morphology; Nasopharynx - microbiology; Older people; Oropharynx - microbiology; Pneumococcal Infections - epidemiology; Pneumococcal Infections - prevention & control; Pneumococcal Vaccines - administration & dosage; Polymerase Chain Reaction; Polysaccharides; Prevalence; respiratory system; Respiratory tract; Risk analysis; Risk Factors; Risk reduction; Serotypes; Serotyping; spring; Streptococcus infections; Streptococcus pneumoniae; Streptococcus pneumoniae - classification; Streptococcus pneumoniae - genetics; Streptococcus pneumoniae - growth & development; Surveillance; Vaccination; Vaccines; winter; Adults; Vaccination; Colonization; Streptococcus pneumoniae

Pneumococcus is a commensal of the upper respiratory tract and colonization is common in young children. Carriage studies have provided insights on vaccine effects in children and may also be useful for assessing vaccines in adults. However, culture based prevalence studies in older adults describe...