Focused Ultrasound Platform for Investigating Therapeutic Neuromodulation Across the Human Hippocampus

• Published in: Ultrasound in medicine & biology Vol. 46; no. 5; pp. 1270 - 1274
• Main Authors: Brinker, Spencer T., Preiswerk, Frank, White, Phillip J., Mariano, Timothy Y., McDannold, Nathan J., Bubrick, Ellen J.
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.05.2020
• Subjects: Adult; Animals; Epilepsy, Temporal Lobe - diagnostic imaging; Epilepsy, Temporal Lobe - therapy; Female; Hippocampus - diagnostic imaging; Human hippocampus; Humans; Low-intensity focused ultrasound; Magnetic Resonance Imaging; Multitarget; Neuronavigation; Neuronavigation - methods; Radiology; Therapeutic neuromodulation; Ultrasonic Therapy - adverse effects; Ultrasonic Therapy - methods; Low-intensity focused ultrasound; Therapeutic neuromodulation; Human hippocampus; Multitarget; Neuronavigation

Pulsed low-intensity focused ultrasound (PLIFUS) has shown promise in inducing neuromodulation in several animal and human studies. Therefore, it is of clinical interest to develop experimental platforms to test repetitive PLIFUS as a therapeutic modality in humans with neurologic disorders. In the...