Genome-wide RNA-Seq identifies TP53-mediated embryonic stem cells inhibiting tumor invasion and metastasis

• Published in: Stem cell research & therapy Vol. 15; no. 1; pp. 369 - 12
• Main Authors: Li, Yatong, Fan, Yongna, Xie, Yunyi, Li, Limin, Li, Juan, Liu, Jingyi, Jin, Zhengyu, Xue, Huadan, Wang, Zhiwei
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 16.10.2024; BioMed Central; BMC
• Subjects: Analysis; Animals; Cancer; Care and treatment; Cell Line, Tumor; Coculture Techniques; Embryonic stem cell; Embryonic stem cells; Embryonic Stem Cells - metabolism; Genomics; Humans; Invasion; Metastasis; Mice; Mice, Inbred C57BL; Neoplasm Invasiveness; Neoplasm Metastasis; Pancreatic cancer; RNA; RNA sequencing; RNA-Seq - methods; Short Report; TP53; Tumor proteins; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; Tumor tropism; China; Embryonic stem cell; Tumor tropism; Metastasis; TP53; Invasion

The discovery of embryonic stem cell (ESC) mediating tumoricidal activity revealed the intimate relationship between ESCs and tumor cells, but the functional role of ESCs in tumor progression is poorly understood. To further investigate tumor cell and ESC interactions, we co-cultured mouse ESCs with...