Genome-wide RNA-Seq identifies TP53-mediated embryonic stem cells inhibiting tumor invasion and metastasis

The discovery of embryonic stem cell (ESC) mediating tumoricidal activity revealed the intimate relationship between ESCs and tumor cells, but the functional role of ESCs in tumor progression is poorly understood. To further investigate tumor cell and ESC interactions, we co-cultured mouse ESCs with...

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Published inStem cell research & therapy Vol. 15; no. 1; pp. 369 - 12
Main Authors Li, Yatong, Fan, Yongna, Xie, Yunyi, Li, Limin, Li, Juan, Liu, Jingyi, Jin, Zhengyu, Xue, Huadan, Wang, Zhiwei
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 16.10.2024
BioMed Central
BMC
Subjects
Analysis
Animals
Cancer
Care and treatment
Cell Line, Tumor
Coculture Techniques
Embryonic stem cell
Embryonic stem cells
Embryonic Stem Cells - metabolism
Genomics
Humans
Invasion
Metastasis
Mice
Mice, Inbred C57BL
Neoplasm Invasiveness
Neoplasm Metastasis
Pancreatic cancer
RNA
RNA sequencing
RNA-Seq - methods
Short Report
TP53
Tumor proteins
Tumor Suppressor Protein p53 - genetics
Tumor Suppressor Protein p53 - metabolism
Tumor tropism
China
Embryonic stem cell
Tumor tropism
Metastasis
TP53
Invasion
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Abstract The discovery of embryonic stem cell (ESC) mediating tumoricidal activity revealed the intimate relationship between ESCs and tumor cells, but the functional role of ESCs in tumor progression is poorly understood. To further investigate tumor cell and ESC interactions, we co-cultured mouse ESCs with mouse pancreatic cancer Pan02 cells or mouse melanoma B16-F10 cells in Transwell, and found that tumor cell invasion was significantly inhibited by ESCs. Application of ESCs to tumor-bearing mice resulted in significant inhibition of tumor metastasis in vivo. RNA-Seq analyses of tumor cell and ESC co-cultures identified TP53 and related signalling as major pathways involved in ESC-mediated inhibition of tumor cell invasion and metastasis, which indicated the potential clinical application of ESCs to treat cancer.
AbstractList The discovery of embryonic stem cell (ESC) mediating tumoricidal activity revealed the intimate relationship between ESCs and tumor cells, but the functional role of ESCs in tumor progression is poorly understood. To further investigate tumor cell and ESC interactions, we co-cultured mouse ESCs with mouse pancreatic cancer Pan02 cells or mouse melanoma B16-F10 cells in Transwell, and found that tumor cell invasion was significantly inhibited by ESCs. Application of ESCs to tumor-bearing mice resulted in significant inhibition of tumor metastasis in vivo. RNA-Seq analyses of tumor cell and ESC co-cultures identified TP53 and related signalling as major pathways involved in ESC-mediated inhibition of tumor cell invasion and metastasis, which indicated the potential clinical application of ESCs to treat cancer.
The discovery of embryonic stem cell (ESC) mediating tumoricidal activity revealed the intimate relationship between ESCs and tumor cells, but the functional role of ESCs in tumor progression is poorly understood. To further investigate tumor cell and ESC interactions, we co-cultured mouse ESCs with mouse pancreatic cancer Pan02 cells or mouse melanoma B16-F10 cells in Transwell, and found that tumor cell invasion was significantly inhibited by ESCs. Application of ESCs to tumor-bearing mice resulted in significant inhibition of tumor metastasis in vivo. RNA-Seq analyses of tumor cell and ESC co-cultures identified TP53 and related signalling as major pathways involved in ESC-mediated inhibition of tumor cell invasion and metastasis, which indicated the potential clinical application of ESCs to treat cancer. Keywords: Embryonic stem cell, Tumor tropism, Invasion, Metastasis, TP53
The discovery of embryonic stem cell (ESC) mediating tumoricidal activity revealed the intimate relationship between ESCs and tumor cells, but the functional role of ESCs in tumor progression is poorly understood. To further investigate tumor cell and ESC interactions, we co-cultured mouse ESCs with mouse pancreatic cancer Pan02 cells or mouse melanoma B16-F10 cells in Transwell, and found that tumor cell invasion was significantly inhibited by ESCs. Application of ESCs to tumor-bearing mice resulted in significant inhibition of tumor metastasis in vivo. RNA-Seq analyses of tumor cell and ESC co-cultures identified TP53 and related signalling as major pathways involved in ESC-mediated inhibition of tumor cell invasion and metastasis, which indicated the potential clinical application of ESCs to treat cancer.
The discovery of embryonic stem cell (ESC) mediating tumoricidal activity revealed the intimate relationship between ESCs and tumor cells, but the functional role of ESCs in tumor progression is poorly understood. To further investigate tumor cell and ESC interactions, we co-cultured mouse ESCs with mouse pancreatic cancer Pan02 cells or mouse melanoma B16-F10 cells in Transwell, and found that tumor cell invasion was significantly inhibited by ESCs. Application of ESCs to tumor-bearing mice resulted in significant inhibition of tumor metastasis in vivo. RNA-Seq analyses of tumor cell and ESC co-cultures identified TP53 and related signalling as major pathways involved in ESC-mediated inhibition of tumor cell invasion and metastasis, which indicated the potential clinical application of ESCs to treat cancer.The discovery of embryonic stem cell (ESC) mediating tumoricidal activity revealed the intimate relationship between ESCs and tumor cells, but the functional role of ESCs in tumor progression is poorly understood. To further investigate tumor cell and ESC interactions, we co-cultured mouse ESCs with mouse pancreatic cancer Pan02 cells or mouse melanoma B16-F10 cells in Transwell, and found that tumor cell invasion was significantly inhibited by ESCs. Application of ESCs to tumor-bearing mice resulted in significant inhibition of tumor metastasis in vivo. RNA-Seq analyses of tumor cell and ESC co-cultures identified TP53 and related signalling as major pathways involved in ESC-mediated inhibition of tumor cell invasion and metastasis, which indicated the potential clinical application of ESCs to treat cancer.
Abstract The discovery of embryonic stem cell (ESC) mediating tumoricidal activity revealed the intimate relationship between ESCs and tumor cells, but the functional role of ESCs in tumor progression is poorly understood. To further investigate tumor cell and ESC interactions, we co-cultured mouse ESCs with mouse pancreatic cancer Pan02 cells or mouse melanoma B16-F10 cells in Transwell, and found that tumor cell invasion was significantly inhibited by ESCs. Application of ESCs to tumor-bearing mice resulted in significant inhibition of tumor metastasis in vivo. RNA-Seq analyses of tumor cell and ESC co-cultures identified TP53 and related signalling as major pathways involved in ESC-mediated inhibition of tumor cell invasion and metastasis, which indicated the potential clinical application of ESCs to treat cancer.
ArticleNumber 369
Audience Academic
Author Jin, Zhengyu
Fan, Yongna
Li, Juan
Li, Yatong
Xie, Yunyi
Liu, Jingyi
Li, Limin
Xue, Huadan
Wang, Zhiwei
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Cites_doi 10.1038/s41374-021-00714-2
10.1002/cncr.35347
10.3389/fbioe.2023.1292785
10.1186/scrt322
10.1002/bimj.201300048
10.1182/blood-2008-09-176198
10.1634/stemcells.22-2-225
10.1073/pnas.97.23.12846
10.3892/etm.2016.2993
10.3322/caac.21820
10.1038/ng1760
10.1186/s13045-021-01208-w
10.1186/s12935-021-01836-9
10.1093/nar/28.1.27
10.1093/nar/gkj102
10.1038/nature10169
10.1002/ijc.31201
10.1186/1753-6561-3-S4-S6
10.1038/cr.2008.40
10.1038/nature12464
10.3322/caac.21824
10.1038/s43018-023-00576-1
10.1007/s00401-005-1038-0
10.1200/JCO.21.02506
10.1038/nchem.1887
10.1016/S0076-6879(06)11013-7
10.3390/cancers14153761
10.3390/mps2040086
10.1371/journal.pmed.0030482
10.1038/s41467-024-46844-1
10.3322/caac.21830
10.1074/jbc.M109.032235
10.1038/nmeth.2330
10.1016/S0092-8674(00)81769-9
10.1038/s41374-020-0429-0
10.1038/35102167
10.1126/science.282.5391.1145
10.1038/292154a0
10.1038/336688a0
10.1093/nar/gkh063
10.4252/wjsc.v14.i1.54
10.3389/fphar.2018.00259
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Issue 1
Keywords Embryonic stem cell
Tumor tropism
Metastasis
TP53
Invasion
Language English
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References DS Dizon (4000_CR1) 2024; 74
4000_CR3
A Facciabene (4000_CR34) 2011; 475
RJ Hill (4000_CR19) 2024; 15
Y Li (4000_CR13) 2018; 142
J Mazar (4000_CR12) 2009; 284
LE Morrison (4000_CR31) 2022; 102
KJ McCarty (4000_CR17) 1985; 109
KW Thiel (4000_CR36) 2022; 40
JF Stoltz (4000_CR42) 2015; 25
DS Chulpanova (4000_CR40) 2018; 9
KS Aboody (4000_CR7) 2000; 97
M Kanehisa (4000_CR25) 2004; 32
DC Hay (4000_CR28) 2004; 22
S Aravindhan (4000_CR41) 2021; 21
L Qiao (4000_CR10) 2008; 18
JR Lin (4000_CR32) 2023; 4
LE Morrison (4000_CR18) 2020; 100
4000_CR30
T Downey (4000_CR20) 2006; 411
G Ramaswami (4000_CR21) 2013; 10
M Kanehisa (4000_CR24) 2006; 34
AG Smith (4000_CR14) 1988; 336
T Lan (4000_CR39) 2021; 14
J Li (4000_CR43) 2014; 6
JA Thomson (4000_CR6) 1998; 282
K Otsu (4000_CR11) 2009; 113
MJ Evans (4000_CR15) 1981; 292
S Beronja (4000_CR27) 2013; 501
JJ Hoozemans (4000_CR35) 2005; 110
C Vicinanza (4000_CR37) 2022; 14
WM Suchorska (4000_CR45) 2016; 11
YH Loh (4000_CR29) 2006; 38
T Reya (4000_CR5) 2001; 414
A Jimenez-Marin (4000_CR22) 2009; 3
I Atsuta (4000_CR8) 2013; 4
SH Jung (4000_CR26) 2014; 56
RL Siegel (4000_CR4) 2024; 74
4000_CR38
J Kim (4000_CR16) 2023; 11
M Kanehisa (4000_CR23) 2000; 28
to Erratum (4000_CR2) 2024; 74
R Fodde (4000_CR9) 2006; 3
4000_CR33
D Ilic (4000_CR44) 2015; 116
References_xml – volume: 102
  start-page: 545
  year: 2022
  ident: 4000_CR31
  publication-title: LAB INVEST
  doi: 10.1038/s41374-021-00714-2
– ident: 4000_CR3
  doi: 10.1002/cncr.35347
– volume: 11
  start-page: 1292785
  year: 2023
  ident: 4000_CR16
  publication-title: Front Bioeng Biotechnol
  doi: 10.3389/fbioe.2023.1292785
– volume: 4
  start-page: 111
  year: 2013
  ident: 4000_CR8
  publication-title: STEM CELL RES THER
  doi: 10.1186/scrt322
– volume: 56
  start-page: 129
  year: 2014
  ident: 4000_CR26
  publication-title: Biom J
  doi: 10.1002/bimj.201300048
– volume: 113
  start-page: 4197
  year: 2009
  ident: 4000_CR11
  publication-title: Blood
  doi: 10.1182/blood-2008-09-176198
– volume: 22
  start-page: 225
  year: 2004
  ident: 4000_CR28
  publication-title: Stem Cells
  doi: 10.1634/stemcells.22-2-225
– volume: 97
  start-page: 12846
  year: 2000
  ident: 4000_CR7
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.97.23.12846
– volume: 11
  start-page: 695
  year: 2016
  ident: 4000_CR45
  publication-title: EXP THER MED
  doi: 10.3892/etm.2016.2993
– volume: 74
  start-page: 12
  year: 2024
  ident: 4000_CR4
  publication-title: CA Cancer J Clin
  doi: 10.3322/caac.21820
– volume: 38
  start-page: 431
  year: 2006
  ident: 4000_CR29
  publication-title: NAT GENET
  doi: 10.1038/ng1760
– volume: 14
  start-page: 195
  year: 2021
  ident: 4000_CR39
  publication-title: J HEMATOL ONCOL
  doi: 10.1186/s13045-021-01208-w
– volume: 21
  start-page: 158
  year: 2021
  ident: 4000_CR41
  publication-title: CANCER CELL INT
  doi: 10.1186/s12935-021-01836-9
– volume: 116
  start-page: 19
  year: 2015
  ident: 4000_CR44
  publication-title: Br Med Bull
– volume: 28
  start-page: 27
  year: 2000
  ident: 4000_CR23
  publication-title: NUCLEIC ACIDS RES
  doi: 10.1093/nar/28.1.27
– volume: 34
  start-page: D354
  year: 2006
  ident: 4000_CR24
  publication-title: NUCLEIC ACIDS RES
  doi: 10.1093/nar/gkj102
– volume: 475
  start-page: 226
  year: 2011
  ident: 4000_CR34
  publication-title: Nature
  doi: 10.1038/nature10169
– volume: 25
  start-page: 3
  year: 2015
  ident: 4000_CR42
  publication-title: Biomed Mater Eng
– volume: 142
  start-page: 1829
  year: 2018
  ident: 4000_CR13
  publication-title: INT J CANCER
  doi: 10.1002/ijc.31201
– volume: 3
  start-page: S6
  issue: Suppl 4
  year: 2009
  ident: 4000_CR22
  publication-title: BMC Proc
  doi: 10.1186/1753-6561-3-S4-S6
– volume: 18
  start-page: 500
  year: 2008
  ident: 4000_CR10
  publication-title: CELL RES
  doi: 10.1038/cr.2008.40
– volume: 501
  start-page: 185
  year: 2013
  ident: 4000_CR27
  publication-title: Nature
  doi: 10.1038/nature12464
– volume: 74
  start-page: 8
  year: 2024
  ident: 4000_CR1
  publication-title: CA Cancer J Clin
  doi: 10.3322/caac.21824
– volume: 4
  start-page: 1036
  year: 2023
  ident: 4000_CR32
  publication-title: Nat Cancer
  doi: 10.1038/s43018-023-00576-1
– volume: 110
  start-page: 165
  year: 2005
  ident: 4000_CR35
  publication-title: ACTA NEUROPATHOL
  doi: 10.1007/s00401-005-1038-0
– volume: 40
  start-page: 3289
  year: 2022
  ident: 4000_CR36
  publication-title: J CLIN ONCOL
  doi: 10.1200/JCO.21.02506
– volume: 6
  start-page: 352
  year: 2014
  ident: 4000_CR43
  publication-title: NAT CHEM
  doi: 10.1038/nchem.1887
– volume: 411
  start-page: 256
  year: 2006
  ident: 4000_CR20
  publication-title: Methods Enzymol
  doi: 10.1016/S0076-6879(06)11013-7
– ident: 4000_CR38
  doi: 10.3390/cancers14153761
– ident: 4000_CR33
  doi: 10.3390/mps2040086
– volume: 3
  start-page: e482
  year: 2006
  ident: 4000_CR9
  publication-title: PLOS MED
  doi: 10.1371/journal.pmed.0030482
– volume: 15
  start-page: 2518
  year: 2024
  ident: 4000_CR19
  publication-title: NAT COMMUN
  doi: 10.1038/s41467-024-46844-1
– volume: 74
  start-page: 203
  year: 2024
  ident: 4000_CR2
  publication-title: CA Cancer J Clin
  doi: 10.3322/caac.21830
– volume: 284
  start-page: 22022
  year: 2009
  ident: 4000_CR12
  publication-title: J BIOL CHEM
  doi: 10.1074/jbc.M109.032235
– volume: 10
  start-page: 128
  year: 2013
  ident: 4000_CR21
  publication-title: NAT METHODS
  doi: 10.1038/nmeth.2330
– ident: 4000_CR30
  doi: 10.1016/S0092-8674(00)81769-9
– volume: 100
  start-page: 1124
  year: 2020
  ident: 4000_CR18
  publication-title: LAB INVEST
  doi: 10.1038/s41374-020-0429-0
– volume: 414
  start-page: 105
  year: 2001
  ident: 4000_CR5
  publication-title: Nature
  doi: 10.1038/35102167
– volume: 282
  start-page: 1145
  year: 1998
  ident: 4000_CR6
  publication-title: Science
  doi: 10.1126/science.282.5391.1145
– volume: 292
  start-page: 154
  year: 1981
  ident: 4000_CR15
  publication-title: Nature
  doi: 10.1038/292154a0
– volume: 336
  start-page: 688
  year: 1988
  ident: 4000_CR14
  publication-title: Nature
  doi: 10.1038/336688a0
– volume: 109
  start-page: 716
  year: 1985
  ident: 4000_CR17
  publication-title: ARCH PATHOL LAB MED
– volume: 32
  start-page: D277
  year: 2004
  ident: 4000_CR25
  publication-title: NUCLEIC ACIDS RES
  doi: 10.1093/nar/gkh063
– volume: 14
  start-page: 54
  year: 2022
  ident: 4000_CR37
  publication-title: WORLD J STEM CELLS
  doi: 10.4252/wjsc.v14.i1.54
– volume: 9
  start-page: 259
  year: 2018
  ident: 4000_CR40
  publication-title: FRONT PHARMACOL
  doi: 10.3389/fphar.2018.00259
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Snippet The discovery of embryonic stem cell (ESC) mediating tumoricidal activity revealed the intimate relationship between ESCs and tumor cells, but the functional...
Abstract The discovery of embryonic stem cell (ESC) mediating tumoricidal activity revealed the intimate relationship between ESCs and tumor cells, but the...
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SubjectTerms Analysis
Animals
Cancer
Care and treatment
Cell Line, Tumor
Coculture Techniques
Embryonic stem cell
Embryonic stem cells
Embryonic Stem Cells - metabolism
Genomics
Humans
Invasion
Metastasis
Mice
Mice, Inbred C57BL
Neoplasm Invasiveness
Neoplasm Metastasis
Pancreatic cancer
RNA
RNA sequencing
RNA-Seq - methods
Short Report
TP53
Tumor proteins
Tumor Suppressor Protein p53 - genetics
Tumor Suppressor Protein p53 - metabolism
Tumor tropism
Title Genome-wide RNA-Seq identifies TP53-mediated embryonic stem cells inhibiting tumor invasion and metastasis
URI https://www.ncbi.nlm.nih.gov/pubmed/39415294
https://www.proquest.com/docview/3117617821
https://pubmed.ncbi.nlm.nih.gov/PMC11483973
https://doaj.org/article/75c473b6bcdd4164b2939fdb0b4d33ff
Volume 15
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