Identification and Functional Characterization of ERK/MAPK Phosphorylation Sites in the Runx2 Transcription Factor

• Published in: The Journal of biological chemistry Vol. 284; no. 47; pp. 32533 - 32543
• Main Authors: Ge, Chunxi, Xiao, Guozhi, Jiang, Di, Yang, Qian, Hatch, Nan E., Roca, Hernan, Franceschi, Renny T.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.11.2009; American Society for Biochemistry and Molecular Biology
• Subjects: Animals; Binding Sites; Cell Line; Chlorocebus aethiops; Core Binding Factor Alpha 1 Subunit - metabolism; COS Cells; DNA, Complementary - metabolism; Extracellular Signal-Regulated MAP Kinases - metabolism; Humans; MAP Kinase Signaling System; Mass Spectrometry - methods; Mice; Mice, Inbred C3H; Phosphorylation; Serine - chemistry; Transcription, Chromatin, and Epigenetics

The Runx2 transcription factor is required for commitment of mesenchymal cells to bone lineages and is a major regulator of osteoblast-specific gene expression. Runx2 is subject to a number of post-transcriptional controls including selective proteolysis and phosphorylation. We previously reported t...