Effects of extracellular magnesium extract on the proliferation and differentiation of human osteoblasts and osteoclasts in coculture

• Published in: Acta biomaterialia Vol. 27; pp. 294 - 304
• Main Authors: Wu, Lili, Feyerabend, Frank, Schilling, Arndt F., Willumeit-Römer, Regine, Luthringer, Bérengère J.C.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2015
• Subjects: Biocompatibility; Biodegradation; Biomedical materials; Bone Substitutes - administration & dosage; Cell Differentiation - drug effects; Cell Differentiation - physiology; Cell Proliferation - drug effects; Cell Proliferation - physiology; Cells, Cultured; Coculture; Coculture Techniques - methods; Culture; Dilution; Dose-Response Relationship, Drug; Extracellular Fluid - chemistry; Humans; Magnesium; Magnesium - administration & dosage; Materials Testing; Mathematical models; Osteoblast; Osteoblasts; Osteoblasts - cytology; Osteoblasts - drug effects; Osteoblasts - physiology; Osteoclast; Osteoclasts - cytology; Osteoclasts - drug effects; Osteoclasts - physiology; Surgical implants; Biodegradation; Osteoblast; Coculture; Osteoclast; Magnesium

[Display omitted] Coculture of osteoblasts and osteoclasts is a subject of interest in the understanding of how magnesium (Mg)-based implants influence the bone metabolism and remodeling upon degradation. Human telomerase reverse transcriptase (hTERT) transduced mesenchymal stem cells (SCP-1) were f...