A bivalent outer membrane vesicle-based intranasal vaccine to prevent infection of periodontopathic bacteria

• Published in: Vaccine Vol. 41; no. 30; pp. 4369 - 4383
• Main Authors: Nakao, Ryoma, Hirayama, Satoru, Yamaguchi, Takehiro, Senpuku, Hidenobu, Hasegawa, Hideki, Suzuki, Tadaki, Akeda, Yukihiro, Ohnishi, Makoto
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 05.07.2023; Elsevier Limited
• Subjects: Actinobacillus actinomycetemcomitans; adjuvants; Aggregatibacter actinomycetemcomitans; Allergy and Immunology; Antigens; Antimicrobial agents; Bacteria; blood serum; brain; Cytokines; Dentistry; Disease; Disorders; Gum disease; Immune response (humoral); Immunization; Immunogenicity; Immunoglobulin A; Immunoglobulin G; Intranasal administration; Lipid A; Lipids; Macrophages; Membrane vesicles; Membranes; mice; Microorganisms; Molecular weight; Morphology; mouth; Mucosa; Oral cavity; Outer membrane vesicles (OMVs); Pathogens; Periodontal disease; Periodontal diseases; Polyinosinic:polycytidylic acid; Porphyromonas gingivalis; Proteins; Public health; Saliva; Teeth; Vaccines; Virulence; Porphyromonas gingivalis; Aggregatibacter actinomycetemcomitans; Outer membrane vesicles (OMVs); Periodontal disease; Vaccines

Periodontal disease has become a serious public health problem, not only causing tooth loss, but also inducing chronic disorders of extra-oral organs. The present study assessed an intranasal vaccine strategy to prevent periodontal disease using outer membrane vesicles (OMVs) of two major periodonto...