A bivalent outer membrane vesicle-based intranasal vaccine to prevent infection of periodontopathic bacteria - Nakao, Ryoma; Hirayama, Satoru; Yamaguchi, Takehiro; Senpuku, Hidenobu; Hasegawa, Hideki; Suzuki, Tadaki; Akeda, Yukihiro; Ohnishi, Makoto (Vaccine, 2023)
Keywords: Actinobacillus actinomycetemcomitans; adjuvants; Aggregatibacter actinomycetemcomitans; Allergy and Immunology; Antigens; Antimicrobial agents; Bacteria; blood serum; brain; Cytokines; Dentistry; Disease; Disorders; Gum disease; Immune response (humoral); Immunization; Immunogenicity; Immunoglobulin A; Immunoglobulin G; Intranasal administration; Lipid A; Lipids; Macrophages; Membrane vesicles; Membranes; mice; Microorganisms; Molecular weight; Morphology; mouth; Mucosa; Oral cavity; Outer membrane vesicles (OMVs); Pathogens; Periodontal disease; Periodontal diseases; Polyinosinic:polycytidylic acid; Porphyromonas gingivalis; Proteins; Public health; Saliva; Teeth; Vaccines; Virulence; Porphyromonas gingivalis; Aggregatibacter actinomycetemcomitans; Outer membrane vesicles (OMVs); Periodontal disease; Vaccines