RET Proto-Oncogene Mutational Analysis in 45 Iranian Patients Affected with Medullary Thyroid Carcinoma: Report of a New Variant

• Published in: Journal of thyroid research Vol. 2021; pp. 1 - 9
• Main Authors: Damavandi, Elia, Vand-Rajabpour, Fatemeh, Javadi-Arjmand, Maliheh, Mohajeri Tehrani, Mohammad-Reza, Larijani, Bagher, Kabuli, Majid, Ghadami, Mohsen
• Format: Journal Article
• Language: English
• Published: United States Hindawi 2021; John Wiley & Sons, Inc
• Subjects: Analysis; Cancer; Carcinoma; DNA sequencing; Ethylenediaminetetraacetic acid; Gene mutations; Genetic aspects; Metastasis; Mutation; Nucleotide sequencing; Polymorphism; Software; Thyroid cancer; Thyroid diseases; Thyroidectomy; Tumors; Iran

Background. The aim of this study was to identify germline mutation of the RET (rearranged during transfection) gene in patients with medullary thyroid carcinoma (MTC) and their first-degree relatives to find presymptomatic carriers for possible prophylactic thyroidectomy. Methods/Patients. We exami...