Airway Hyperresponsiveness, Inflammation, and Pulmonary Emphysema in Rodent Models Designed to Mimic Exposure to Fuel Oil–Derived Volatile Organic Compounds Encountered during an Experimental Oil Spill

• Published in: Environmental health perspectives Vol. 128; no. 2; p. 27003
• Main Authors: Amor-Carro, Óscar, White, Kathryn M., Fraga-Iriso, Rebeca, Mariñas-Pardo, Luis A., Núñez-Naveira, Laura, Lema-Costa, Beatriz, Villarnovo, Marta, Verea-Hernando, Héctor, Ramos-Barbón, David
• Format: Journal Article
• Language: English
• Published: United States National Institute of Environmental Health Sciences 01.02.2020; Environmental Health Perspectives
• Subjects: Alveoli; Animal diseases; Animal models; Animals; Apoptosis; Bronchus; Chronic obstructive lung disease; Chronic obstructive pulmonary disease; Cigarette smoke; Damage; Data collection; Decontamination; Diseases; DNA; DNA damage; Emphysema; Endothelial growth factors; Endothelium; Environmental cleanup; Exposure; Fuel oil industry; Fuel oils; Growth factors; Histochemistry; Histopathology; House mouse; Human subjects; Hypotheses; Inflammation; Inhalation; Lung diseases; Marine accidents; Medical research; Methacholine; Microvasculature; Mimicry; Morphology; Novels; Obstructive lung disease; Oil drilling rigs; Oil spills; Organic compounds; Parenchyma; Ports; Respiration; Respiratory diseases; Respiratory tract; Respiratory tract diseases; Rodents; Smoking; Spirometry; Tankers; Tankers (Ships); Vascular endothelial growth factor; VOCs; Volatile organic compounds; Norway; Spain

Fuel oil-derived volatile organic compounds (VOCs) inhalation is associated with accidental marine spills. After the petroleum tanker sank off northern Spain in 2002 and the oil rig catastrophe in 2009, subjects involved in environmental decontamination showed signs of ongoing or residual lung disea...