Multi-transcriptomic analysis points to early organelle dysfunction in human astrocytes in Alzheimer's disease

• Published in: Neurobiology of disease Vol. 166; p. 105655
• Main Authors: Galea, Elena, Weinstock, Laura D., Larramona-Arcas, Raquel, Pybus, Alyssa F., Giménez-Llort, Lydia, Escartin, Carole, Wood, Levi B.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2022; Elsevier
• Subjects: Alzheimer Disease - metabolism; Alzheimer's disease; Astrocytes; Astrocytes - metabolism; Cognitive Dysfunction - complications; Gene Expression Profiling; Hierarchical clustering; Humans; Life Sciences; MCI; Mitochondria; Neurons and Cognition; Organelles - metabolism; Perisynaptic astrocyte processes; RNA seq; Transcriptome; MCI; Mitochondria; Astrocytes; Perisynaptic astrocyte processes; RNA seq; Hierarchical clustering; Alzheimer's disease

The phenotypic transformation of astrocytes in Alzheimer's disease (AD) is still not well understood. Recent analyses based on single-nucleus RNA sequencing of postmortem Alzheimer's disease (AD) samples are limited by the low number of sequenced astrocytes, small cohort sizes, and low num...