Regulation of axonal caliber, neurofilament content, and nuclear localization in mature sensory neurons by nerve growth factor

• Published in: The Journal of neuroscience Vol. 11; no. 4; pp. 943 - 955
• Main Authors: Gold, BG, Mobley, WC, Matheson, SF
• Format: Journal Article
• Language: English
• Published: Washington, DC Soc Neuroscience 01.04.1991; Society for Neuroscience
• Subjects: Animals; Axons - ultrastructure; Biological and medical sciences; Cell Nucleus - ultrastructure; Cell Survival; Fundamental and applied biological sciences. Psychology; Immune Sera - immunology; Intermediate Filaments - immunology; Intermediate Filaments - ultrastructure; Isolated neuron and nerve. Neuroglia; Nerve Growth Factors - pharmacology; Neurons, Afferent - ultrastructure; Sciatic Nerve - drug effects; Sciatic Nerve - ultrastructure; Vertebrates: nervous system and sense organs; Spinal cord; Rat; Rodentia; Central nervous system; Axon; Nerve growth factor; Vertebrata; Neurofilament; Mammalia; Transmission electron microscopy; Sensory neuron; Spinal ganglion; Lesion; Localization; Morphometry; Sciatic nerve

The neuronal perikaryal response to axonal injury (axon reaction) includes reduction in axonal caliber beginning in the proximal portion of the nerve (somatofugal axonal atrophy), development of nuclear eccentricity, and chromatolysis. The means by which these events are triggered is unknown, but it...