Non-protein-bound iron and 4-hydroxynonenal protein adducts in classic autism

• Published in: Brain & development (Tokyo. 1979) Vol. 35; no. 2; pp. 146 - 154
• Main Authors: Pecorelli, Alessandra, Leoncini, Silvia, De Felice, Claudio, Signorini, Cinzia, Cerrone, Cosimina, Valacchi, Giuseppe, Ciccoli, Lucia, Hayek, Joussef
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2013
• Subjects: 4-Hydroxynonenal; 4-hydroxynonenal protein adducts; Adolescent; Adult; Age; Aldehydes - blood; Antioxidants; Autism; Autistic Disorder - blood; Blotting, Western; Child; Child, Preschool; Chromatography, High Pressure Liquid; Diagnostic and Statistical Manual of Mental Disorders; Erythrocyte Membrane - chemistry; Erythrocytes; Erythrocytes - chemistry; Female; Free iron; Glutathione; Glutathione - blood; High-performance liquid chromatography; Humans; Intelligence Tests; Iron; Lipid peroxidation; Male; Neurodevelopment disorders; Neurology; Neuropsychological Tests; Nonheme Iron Proteins - blood; Oxidative stress; Oxidative Stress - physiology; Plasma - chemistry; Protein adducts; Spectrophotometry; Western blotting; Young Adult; Lipid peroxidation; Oxidative stress; Free iron; 4-hydroxynonenal protein adducts; Neurodevelopment disorders

A link between oxidative stress and autism spectrum disorders (ASDs) remains controversial with opposing views on its role in the pathogenesis of the disease. We investigated for the first time the levels of non-protein-bound iron (NPBI), a pro-oxidant factor, and 4-hydroxynonenal protein adducts (4...