Decreased benzodiazepine receptor and increased GABA level in cortical tubers in tuberous sclerosis complex

• Published in: Brain & development (Tokyo. 1979) Vol. 34; no. 6; pp. 478 - 486
• Main Authors: Mori, Kenji, Mori, Tatsuo, Toda, Yoshihiro, Fujii, Emiko, Miyazaki, Masahito, Harada, Masafumi, Kagami, Shoji
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2012
• Subjects: Aspartic Acid - analogs & derivatives; Aspartic Acid - metabolism; Benzodiazepine receptors; Brain; Brain - diagnostic imaging; Brain - metabolism; Case-Control Studies; Child; Child, Preschool; Children; Cortex; Epilepsy; Female; Flumazenil - analogs & derivatives; GABA; gamma -Aminobutyric acid; gamma -Aminobutyric acid receptors; gamma-Aminobutyric Acid - metabolism; Glutamate; Glutamic acid; Glutamic Acid - metabolism; Humans; Inositol - metabolism; Iodine Radioisotopes; Iomazenil SPECT; Magnetic resonance imaging; Magnetic Resonance Spectroscopy; Male; N-Acetylaspartate; Neurology; Parietal lobe; Proton MRS; Protons; Radiopharmaceuticals; Receptors, GABA-A - metabolism; Single photon emission computed tomography; Spectroscopy; Steam; Temporal lobe; Tomography, Emission-Computed, Single-Photon; Tuberous sclerosis; Tuberous Sclerosis - diagnostic imaging; Tuberous Sclerosis - metabolism; Tuberous sclerosis; GABA; Glutamate; Proton MRS; Iomazenil SPECT

To elucidate the functional characteristics of cortical tubers that might be responsible for epilepsy in tuberous sclerosis complex (TSC), proton magnetic resonance spectroscopy (1H-MRS) and [123I] iomazenil (123I-IMZ) single photon emission computed tomography (SPECT) were performed. 1H-MRS using a...