Highly sensitive droplet digital PCR for detection of RET fusion in papillary thyroid cancer

• Published in: BMC cancer Vol. 23; no. 1; pp. 363 - 9
• Main Authors: Chen, Mengke, Xue, Junyu, Sang, Ye, Jiang, Wenting, He, Weiman, Hong, Shubin, Lv, Weiming, Xiao, Haipeng, Liu, Rengyun
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 20.04.2023; BioMed Central; BMC
• Subjects: Analysis; Annealing; Cancer; Care and treatment; ddPCR; Diagnosis; DNA sequencing; Gene mutations; Genetic aspects; Genomics; Health aspects; Humans; Infection; Metastasis; Methods; Molecular diagnosis; Nucleotide sequencing; Oncogene Proteins, Fusion - genetics; Polymerase Chain Reaction; Prevention; Proto-Oncogene Proteins c-ret - genetics; Radiation, Background; RET fusion; Risk factors; Testing; Thyroid cancer; Thyroid Cancer, Papillary - pathology; Thyroid Neoplasms - genetics; Thyroid Neoplasms - pathology; China; ddPCR; Molecular diagnosis; Thyroid cancer; RET fusion

Thyroid cancer is the most frequent malignancy of the endocrine system, of which papillary thyroid cancer (PTC) is the predominant form with a rapid increasing incidence worldwide. Rearranged during transfection (RET) fusions are common genetic drivers of PTC and the potent RET inhibitor selpercatin...