Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system

• Published in: Brain, behavior, and immunity Vol. 22; no. 3; pp. 301 - 311
• Main Authors: Chen, Jing, Buchanan, Jessica B, Sparkman, Nathan L, Godbout, Jonathan P, Freund, Gregory G, Johnson, Rodney W
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.03.2008
• Subjects: Aging; Aging - metabolism; Aging - psychology; Allergy and Immunology; Animals; Cognition - drug effects; Cytokines - genetics; Escherichia coli; Hippocampus; Hippocampus - drug effects; Hippocampus - metabolism; Hippocampus - pathology; Immunity, Innate - drug effects; Immunohistochemistry - methods; Inflammation Mediators - metabolism; Injections, Intraperitoneal; Interleukin-1; Laser capture microdissection; Lasers; Lipopolysaccharide; Lipopolysaccharides - administration & dosage; Lipopolysaccharides - pharmacology; Male; Maze Learning - drug effects; Memory - drug effects; Mice; Mice, Inbred BALB C; Microdissection - methods; Microglia - pathology; Psychiatry; RNA, Messenger - metabolism; Staining and Labeling; Swimming; Working memory; Aging; Lipopolysaccharide; Laser capture microdissection; Interleukin-1; Working memory; Hippocampus

Abstract Acute cognitive disorders are common in elderly patients with peripheral infections but it is not clear why. Here, we injected old and young mice with Escherichia coli lipopolysaccharide (LPS) to mimic an acute peripheral infection and separated the hippocampal neuronal cell layers from the...