Intravenous administration of LPS activates the kynurenine pathway in healthy male human subjects: a prospective placebo-controlled cross-over trial

• Published in: Journal of neuroinflammation Vol. 18; no. 1; pp. 158 - 11
• Main Authors: Millischer, Vincent, Heinzl, Matthias, Faka, Anthi, Resl, Michael, Trepci, Ada, Klammer, Carmen, Egger, Margot, Dieplinger, Benjamin, Clodi, Martin, Schwieler, Lilly
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.07.2021; BioMed Central; BMC
• Subjects: Acids; Administration, Intravenous; Adolescent; Adult; Bacteremia; Bacterial infections; C-reactive protein; C-Reactive Protein - analysis; C-Reactive Protein - metabolism; Catheters; Cellular signal transduction; Cognitive ability; Cross-Over Studies; Cytokines; Development and progression; E coli; Electrocardiography; Endotoxemia; Experimental endotoxemia; Gas flow; Gram-negative bacteria; Health aspects; Human experimentation in medicine; Human subjects; Humans; Immune system; Infections; Inflammation; Injection; Interleukin 6; Interleukin-6 - blood; Interleukin-6 - metabolism; Intravenous administration; Kinases; Kynurenic acid; Kynurenine - blood; Kynurenine - metabolism; Kynurenine metabolites; Lipopolysaccharides; Lipopolysaccharides (LPS); Lipopolysaccharides - administration & dosage; Lipopolysaccharides - immunology; Lipopolysaccharides - metabolism; Male; Metabolites; Neuroprotection; Neurotoxicity; Picolinic acid; Placebos; Plasma; Prospective Studies; Proteins; Quinolinic acid; Research Subjects; Self-experimentation in medicine; Single-Blind Method; Standard deviation; Tryptophan; Tryptophan - blood; Tryptophan - metabolism; Tumor necrosis factor-TNF; Sweden; Canada; United States > US; Inflammation; Lipopolysaccharides (LPS); Experimental endotoxemia; Kynurenine metabolites
• ISSN: 1742-2094; 1742-2094
• DOI: 10.1186/s12974-021-02196-x

Administration of lipopolysaccharide (LPS) from Gram-negative bacteria, also known as the human endotoxemia model, is a standardized and safe model of human inflammation. Experimental studies have revealed that peripheral administration of LPS leads to induction of the kynurenine pathway followed by...