Ultra-Sensitive TP53 Sequencing for Cancer Detection Reveals Progressive Clonal Selection in Normal Tissue over a Century of Human Lifespan - Salk, Jesse J.; Loubet-Senear, Kaitlyn; Maritschnegg, Elisabeth; Valentine, Charles C.; Williams, Lindsey N.; Higgins, Jacob E.; Horvat, Reinhard; Vanderstichele, Adriaan; Nachmanson, Daniela; Baker, Kathryn T.; Emond, Mary J.; Loter, Emily; et al. (Cell reports (Cambridge), 2019)
Keywords: Adult; Aged; Aged, 80 and over; aging; Aging - genetics; Biochemistry, Molecular Biology; Cancer; Cell-Free Nucleic Acids - genetics; Clonal Evolution - genetics; Databases, Genetic; DNA, Neoplasm - genetics; Duplex Sequencing; early detection; Female; Genomics; gynecologic oncology; high-grade serous ovarian cancer; High-Throughput Nucleotide Sequencing; Humans; Infant, Newborn; Life Sciences; Middle Aged; Mutation; next-generation sequencing; Ovarian Neoplasms - diagnosis; Ovarian Neoplasms - genetics; Ovarian Neoplasms - pathology; Selection, Genetic; Sequence Analysis, DNA; somatic mutations; TP53, clonal evolution; Tumor Suppressor Protein p53 - genetics; uterine lavage; Uterus - metabolism; somatic mutations; uterine lavage; next-generation sequencing; high-grade serous ovarian cancer; TP53, clonal evolution; Duplex Sequencing; gynecologic oncology; early detection; aging; clonal evolution; TP53