Detection of Acute Infections during HIV Testing in North Carolina

• Published in: The New England journal of medicine Vol. 352; no. 18; pp. 1873 - 1883
• Main Authors: Pilcher, Christopher D, Fiscus, Susan A, Nguyen, Trang Q, Foust, Evelyn, Wolf, Leslie, Williams, Del, Ashby, Rhonda, O'Dowd, Judy Owen, McPherson, J. Todd, Stalzer, Brandt, Hightow, Lisa, Miller, William C, Eron, Joseph J, Cohen, Myron S, Leone, Peter A
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 05.05.2005
• Subjects: Acute Disease; Adult; Algorithms; Biological and medical sciences; Blotting, Western; Contact Tracing; Costs and Cost Analysis; Diagnostic tests; Effectiveness studies; Female; General aspects; HIV; HIV Antibodies - blood; HIV Infections - diagnosis; HIV Infections - epidemiology; HIV Infections - immunology; HIV Infections - transmission; HIV-1 - genetics; HIV-1 - isolation & purification; Human immunodeficiency virus; Human viral diseases; Humans; Immunoenzyme Techniques; Incidence; Infections; Infectious diseases; Male; Medical sciences; North Carolina - epidemiology; Nucleic Acid Amplification Techniques - economics; RNA, Viral - blood; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; North Carolina; United States; North America; America; United States > US; USA, North Carolina; Infection; Medicine; Immunopathology; Viral disease; Acute; AIDS; Diagnosis; Detection; Immune deficiency

Standard antibody screening does not detect recent infection in persons who have viremia but are antibody-negative. In North Carolina, nucleic acid amplification testing for HIV was added to the screening of 109,250 subjects who were tested during one year. A total of 23 acutely infected subjects we...