Intratumoral heterogeneity in cancer progression and response to immunotherapy

• Published in: Nature medicine Vol. 27; no. 2; pp. 212 - 224
• Main Authors: Vitale, Ilio, Shema, Efrat, Loi, Sherene, Galluzzi, Lorenzo
• Format: Journal Article
• Language: English
• Published: United States Nature Publishing Group 01.02.2021
• Subjects: Care and treatment; Development and progression; Disease Progression; Drug Resistance, Neoplasm - genetics; Genetic aspects; Genetic Heterogeneity; Heterogeneity; Humans; Immunologic Factors - genetics; Immunology; Immunotherapy; Medical treatment; Microenvironments; Neoplasms - genetics; Neoplasms - immunology; Neoplasms - pathology; Patient outcomes; Tumor Microenvironment - genetics; Tumor Microenvironment - immunology; Tumors; Italy

Most (if not all) tumors emerge and progress under a strong evolutionary pressure imposed by trophic, metabolic, immunological, and therapeutic factors. The relative impact of these factors on tumor evolution changes over space and time, ultimately favoring the establishment of a neoplastic microenv...