The molecular function of kallikrein‐related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer

• Published in: Molecular oncology Vol. 14; no. 1; pp. 105 - 128
• Main Authors: Kryza, Thomas, Bock, Nathalie, Lovell, Scott, Rockstroh, Anja, Lehman, Melanie L., Lesner, Adam, Panchadsaram, Janaththani, Silva, Lakmali Munasinghage, Srinivasan, Srilakshmi, Snell, Cameron E., Williams, Elizabeth D., Fazli, Ladan, Gleave, Martin, Batra, Jyotsna, Nelson, Colleen, Tate, Edward W., Harris, Jonathan, Hooper, John D., Clements, Judith A.
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.01.2020; John Wiley and Sons Inc; Wiley
• Subjects: Agrin; Analysis; Androgens; Antigens; Antimitotic agents; Antineoplastic agents; Cancer therapies; castrate‐resistant prostate cancer; Cell Line, Tumor; Cell Movement - genetics; Cell Proliferation - genetics; Chromatography, High Pressure Liquid; Databases, Genetic; Down-Regulation; Ethylenediaminetetraacetic acid; Experiments; Gene expression; Gene Expression Regulation, Neoplastic - genetics; Genomes; Humans; Immunohistochemistry; Interleukin 1; Kallikrein; Kallikreins - genetics; Kallikreins - metabolism; kallikrein‐related peptidase; Kinases; Male; Metastases; Metastasis; Midkine; Molecular modelling; Neoadjuvant Therapy; Neoplasm Metastasis - genetics; Patients; Peptidase; Prostate cancer; Prostatic Neoplasms - enzymology; Prostatic Neoplasms - genetics; Prostatic Neoplasms - metabolism; Prostatic Neoplasms - pathology; protease; protease‐substrate; Protein kinase; Protein kinases; Proteins; Proteomics; Scientific equipment and supplies industry; Serine; Signal Transduction - genetics; Tandem Mass Spectrometry; Transcriptome; Tumor Microenvironment - genetics; Tumors; Up-Regulation; Vitronectin; Australia; United States; United States > US; protease; protease-substrate; prostate cancer; metastasis; kallikrein-related peptidase; castrate-resistant prostate cancer

Kallikrein‐related peptidase 14 (KLK14) is one of the several secreted KLK serine proteases involved in prostate cancer (PCa) pathogenesis. While relatively understudied, recent reports have identified KLK14 as overexpressed during PCa development. However, the modulation of KLK14 expression during...