Fruit juice inhibition of uptake transport: a new type of food–drug interaction

• Published in: British journal of clinical pharmacology Vol. 70; no. 5; pp. 645 - 655
• Main Author: Bailey, David G.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.11.2010; Blackwell; Blackwell Science Inc
• Subjects: Administration, Oral; Anti-Allergic Agents - pharmacokinetics; Atenolol; Beverages; Bioavailability; Biological and medical sciences; Biological Availability; Ciprofloxacin; Citrus; Citrus paradisi; Data processing; drug interaction; Drugs; Etoposide; Fexofenadine; Flavonoids; Food; Food-Drug Interactions - physiology; Fruit juices; Fruits; grapefruit; Histamine H1 Antagonists, Non-Sedating - pharmacokinetics; Humans; Intestine; MDR1; Medical sciences; OATP1A2; orange; Organic Anion Transporters - metabolism; Pharmacology. Drug treatments; review; Reviews; Terfenadine - analogs & derivatives; Terfenadine - pharmacokinetics; Thyroxine; Vegetables; Biological transport; OATP1A2; Review; Fruit juice; Uptake; Food drug interaction; orange; MDR1; MDR-1 gene; Grapefruit; Inhibitor; Drug interaction; Bibliographic review

A new type of interaction in which fruit juices diminish oral drug bioavailability through inhibition of uptake transport is the focus of this review. The discovery was based on an opposite to anticipated finding when assessing the possibility of grapefruit juice increasing oral fexofenadine bioavai...