Genetic Polymorphism of NAT2 Metabolizing Enzymes on Phenytoin Pharmacokinetics in Indian Epileptic Patients Developing Toxicity

• Published in: CNS neuroscience & therapeutics Vol. 18; no. 4; pp. 350 - 358
• Main Authors: Murali, M., Manjari, T., Madhuri, B., Raghavan, S., Jain, D.C., Vivekanandhan, S.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.04.2012; Wiley-Blackwell; John Wiley & Sons, Inc
• Subjects: Adolescent; Adult; Antiepileptic agents; Arylamine N-Acetyltransferase - genetics; Arylamine N-Acetyltransferase - metabolism; Biological and medical sciences; Central nervous system; Computer programs; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Drugs; Enzymes; Epilepsy; Epilepsy - blood; Epilepsy - epidemiology; Epilepsy - genetics; Female; Gene Frequency - genetics; Gene polymorphism; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; High-performance liquid chromatography; Humans; India - epidemiology; Male; Medical sciences; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis; NAT2 enzymes; Nervous system; Nervous system (semeiology, syndromes); Neurology; Original; Pharmacokinetics; Phenytoin; Phenytoin - adverse effects; Phenytoin - blood; Phenytoin - pharmacokinetics; Plasma levels; Polymerase chain reaction; Polymorphism; Polymorphism, Genetic; Restriction fragment length polymorphism; software; Toxicity; Young Adult; India; Human; Nervous system diseases; Enzyme; Toxicity; Epilepsy; Central nervous system disease; Indian; Pharmacokinetics; NAT2 enzymes; Phenytoin; Cerebral disorder; Polymorphism

SUMMARY  Objective: To investigate the effects of NAT2 metabolizing enzymes on the pharmacokinetics of antiepileptic drug phenytoin in the epileptic patients showing toxicity. Methods: Fifty epileptic individuals who had developed toxicity to phenytoin and 50 control epileptic subjects who had not d...