碘化亚铜/亚磷酸三乙酯催化碘代芳烃和末端炔烃的偶联反应

以廉价的亚磷酸三乙酯为配体,首次用于Cu催化的碘代芳烃和末端炔烃的偶联反应,考察了不同Cu盐、金属纯度、碱和催化剂用量等条件对反应性能的影响.结果表明,当以高纯度的CuI（99.999%）为铜源,催化剂用量为5mol%时,在KOH作用下,该催化体系成功催化了一系列碘代芳烃和末端炔烃的反应,表现出良好的催化活性,此外,该催化体系还可用于2-苯基苯并呋喃的合成,为该类化合物的合成提供了一条较为经济的途径....

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Bibliographic Details
Published in催化学报 Vol. 32; no. 8; pp. 1376 - 1379
Main Author 何亭 葛轶岑 武垒垒
Format Journal Article
LanguageChinese
Published 四川大学化学学院有机金属络合催化研究所,教育部绿色化学与技术重点实验室,四川成都610064 2011
Subjects
亚磷酸三乙酯
偶联反应
末端炔烃
碘代芳烃
碘化亚铜
碘代芳烃
末端炔烃
偶联反应
碘化亚铜
亚磷酸三乙酯
Online AccessGet full text
ISSN0253-9837
1872-2067
DOI10.3724/SP.J.1088.2011.10311

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Summary:以廉价的亚磷酸三乙酯为配体,首次用于Cu催化的碘代芳烃和末端炔烃的偶联反应,考察了不同Cu盐、金属纯度、碱和催化剂用量等条件对反应性能的影响.结果表明,当以高纯度的CuI（99.999%）为铜源,催化剂用量为5mol%时,在KOH作用下,该催化体系成功催化了一系列碘代芳烃和末端炔烃的反应,表现出良好的催化活性,此外,该催化体系还可用于2-苯基苯并呋喃的合成,为该类化合物的合成提供了一条较为经济的途径.
Bibliography:HE Ting,GE Yicen,WU Leilei,FU Haiyan,CHEN Hua＊,LI Xianjun Institute of Homogeneous Catalysis,Faculty of Chemistry,Key Laboratory of Green Chemistry and Technology of Ministry of Education,Sichuan University,Chengdu 610064,Sichuan,China
21-1195/O6
cuprous iodide; triethyl phosphite; aryl iodide; alkyne; cross-coupling reaction
The commercially available ligand P（OCH2CH3）3 was first used in the copper catalyzed cross-coupling reaction of aryl iodides with alkynes.The influences of different copper salts,metal purity,bases,and catalyst dosages were investigated.The results indicate that the coupling of a broad range of aryl iodides with alkynes can be catalyzed by the system of 5 mol% CuI/P（OCH2CH3）3 efficiently.In addition,this catalyst also exhibits good activity in the synthesis of 2-phenyl-benzofuran in one pot,which provides an economical way for the syn-thesis of similar compounds.
ISSN:0253-9837
1872-2067
DOI:10.3724/SP.J.1088.2011.10311