慢性疼痛中脊髓小胶质细胞激活机制的研究进展
慢性疼痛中,神经元-脊髓小胶质细胞间的信号分子可以激活脊髓小胶质细胞,而激活的脊髓小胶质细胞可以释放多种与慢性疼痛有关的活性物质。实验研究表明,脊髓小胶质细胞表面受体的上调及细胞内激酶的激活在细胞的激活和慢性疼痛的发生和发展中起重要作用。...
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| Published in | 复旦学报（医学版） Vol. 39; no. 3; pp. 324 - 326 |
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| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
南昌大学第二附属医院麻醉科 南昌330000%复旦大学附属中山医院麻醉科 上海200032
2012
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1672-8467 |
| DOI | 10.3969/j.issn.1672-8467.2012.03.021 |
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| Abstract | 慢性疼痛中,神经元-脊髓小胶质细胞间的信号分子可以激活脊髓小胶质细胞,而激活的脊髓小胶质细胞可以释放多种与慢性疼痛有关的活性物质。实验研究表明,脊髓小胶质细胞表面受体的上调及细胞内激酶的激活在细胞的激活和慢性疼痛的发生和发展中起重要作用。 |
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| AbstractList | 慢性疼痛中,神经元-脊髓小胶质细胞间的信号分子可以激活脊髓小胶质细胞,而激活的脊髓小胶质细胞可以释放多种与慢性疼痛有关的活性物质。实验研究表明,脊髓小胶质细胞表面受体的上调及细胞内激酶的激活在细胞的激活和慢性疼痛的发生和发展中起重要作用。 R363; 慢性疼痛中,神经元-脊髓小胶质细胞间的信号分子可以激活脊髓小胶质细胞,而激活的脊髓小胶质细胞可以释放多种与慢性疼痛有关的活性物质.实验研究表明,脊髓小胶质细胞表面受体的上调及细胞内激酶的激活在细胞的激活和慢性疼痛的发生和发展中起重要作用. |
| Author | 肖凡 朱彪 廖庆武 罗振中 |
| AuthorAffiliation | 南昌大第二附属医院麻醉科,南昌330000 复旦大学附属中山医院麻醉科,上海200032 |
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| Author_FL | XIAO Fan LUO Zhen-zhong LIAO Qing-wu ZHU Biao |
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| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
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| Keywords | 神经性疼痛 丝裂原活化蛋白激酶( MAPKs) 受体 小胶质细胞 |
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| Notes | microglia; neuropathic pain; receptor; mitogen-activated protein kinases（MAPKs） XIAO Fan,ZHU Biao,LIAO Qing-wu,LUO Zhen-zhong（1Department of Anesthesiology,Second Affiliated Hospital,Nanchang University, Nanchang 330000,Jiangxi Province,China;2 Department of Anesthesiology, Zhongshan Hospital,Fudan University,Shanghai 200032,China） Many substances can activate microglia in the spinal cord,and activated microglia in the spinal cord can release a variety of active and pain-related substances.Experimental studies have shown that spinal cord microglia cell surface receptors and intracellular kinase activations play important roles in cell activation and chronic pain. 31-1885/R |
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| Publisher | 南昌大学第二附属医院麻醉科 南昌330000%复旦大学附属中山医院麻醉科 上海200032 |
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| Snippet | 慢性疼痛中,神经元-脊髓小胶质细胞间的信号分子可以激活脊髓小胶质细胞,而激活的脊髓小胶质细胞可以释放多种与慢性疼痛有关的活性物质。实验研究表明,脊髓小胶质细胞表面受体的上调及细胞内激酶的激活在细胞的激活和慢性疼痛的发生和发展中起重要作用。 R363; 慢性疼痛中,神经元-脊髓小胶质细胞间的信号分子可以激活脊髓小胶质细胞,而激活的脊髓小胶质细胞可以释放多种与慢性疼痛有关的活性物质.实验研究表明,脊髓小胶质细胞表面受体的上调及细胞内激酶的激活在细胞的激活和慢性疼痛的发生和发展中起重要作用. |
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| StartPage | 324 |
| SubjectTerms | 丝裂原活化蛋白激酶（MAPKs） 受体 小胶质细胞 神经性疼痛 |
| Title | 慢性疼痛中脊髓小胶质细胞激活机制的研究进展 |
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