Near-infrared spiroximetry: noninvasive measurements of venous saturation in piglets and human subjects

1  Bioengineering Center, Department of Electrical Engineering and Computer Science Tufts University, Medford 02155-6013; and 2  NMR Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129 We present a noninvasive method to measure the venous oxygen saturatio...

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Published inJournal of applied physiology (1985) Vol. 92; no. 1; pp. 372 - 384
Main Authors Franceschini, Maria Angela, Boas, David A, Zourabian, Anna, Diamond, Solomon G, Nadgir, Shalini, Lin, David W, Moore, John B, Fantini, Sergio
Format Journal Article
LanguageEnglish
Published Bethesda, MD Am Physiological Soc 01.01.2002
American Physiological Society
Subjects
Adult
Algorithms
Animals
Biological and medical sciences
Blood
Blood gas. Hemoglobin. Myoglobin. Hemotissulary gas exchange. Acid-base balance
Exercise - physiology
Female
Fundamental and applied biological sciences. Psychology
Hemoglobin
Hindlimb - blood supply
Humans
Infrared spectroscopy
Male
Oximetry - methods
Oxygen
Oxygen - blood
Regional Blood Flow - physiology
Respiration
Spectroscopy, Near-Infrared
Spectrum analysis
Spirometry - methods
Swine
Tissues
Vertebrates: respiratory system
Human
Oxygen
Venous blood
Pulse oxymetry
Saturation
Frequency domain method
Pig
Near infrared spectrometry
Tissue
Vertebrata
Mammalia
Non invasive method
Hemoglobin
Artiodactyla
Measurement method
Ungulata
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Abstract 1  Bioengineering Center, Department of Electrical Engineering and Computer Science Tufts University, Medford 02155-6013; and 2  NMR Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129 We present a noninvasive method to measure the venous oxygen saturation (Sv O 2 ) in tissues using near-infrared spectroscopy (NIRS). This method is based on the respiration-induced oscillations of the near-infrared absorption in tissues, and we call it spiroximetry (the prefix spiro means respiration). We have tested this method in three piglets (hind leg) and in eight human subjects (vastus medialis and vastus lateralis muscles). In the piglet study, we compared our NIRS measurements of the Sv O 2 (Sv O 2 -NIRS resp ) with the Sv O 2 of blood samples. Sv O 2 -NIRS resp and Sv O 2 of blood samples agreed well over the whole range of Sv O 2 considered (20-95%). The two measurements showed an average difference of 1.0% and a standard deviation of the difference of 5.8%. In the human study, we found a good agreement between Sv O 2 -NIRS resp and the Sv O 2 values measured with the NIRS venous occlusion method. Finally, in a preliminary test involving muscle exercise, Sv O 2 -NIRS resp showed an expected postexercise decrease from the initial baseline value and a subsequent recovery to baseline. tissue spectroscopy; frequency-domain; pulse oximetry; hemoglobin saturation
AbstractList We present a noninvasive method to measure the venous oxygen saturation (SVo2) in tissues using near-infrared spectroscopy (NIRS). This method is based on the respiration-induced oscillations of the near-infrared absorption in tissues, and we call it spiroximetry (the prefix spiro means respiration).
We present a noninvasive method to measure the venous oxygen saturation (Sv O 2 ) in tissues using near-infrared spectroscopy (NIRS). This method is based on the respiration-induced oscillations of the near-infrared absorption in tissues, and we call it spiroximetry (the prefix spiro means respiration). We have tested this method in three piglets (hind leg) and in eight human subjects (vastus medialis and vastus lateralis muscles). In the piglet study, we compared our NIRS measurements of the Sv O 2 (Sv O 2 -NIRS resp ) with the Sv O 2 of blood samples. Sv O 2 -NIRS resp and Sv O 2 of blood samples agreed well over the whole range of Sv O 2 considered (20–95%). The two measurements showed an average difference of 1.0% and a standard deviation of the difference of 5.8%. In the human study, we found a good agreement between Sv O 2 -NIRS resp and the Sv O 2 values measured with the NIRS venous occlusion method. Finally, in a preliminary test involving muscle exercise, Sv O 2 -NIRS resp showed an expected postexercise decrease from the initial baseline value and a subsequent recovery to baseline.
We present a noninvasive method to measure the venous oxygen saturation (Sv(O(2))) in tissues using near-infrared spectroscopy (NIRS). This method is based on the respiration-induced oscillations of the near-infrared absorption in tissues, and we call it spiroximetry (the prefix spiro means respiration). We have tested this method in three piglets (hind leg) and in eight human subjects (vastus medialis and vastus lateralis muscles). In the piglet study, we compared our NIRS measurements of the Sv(O(2)) (Sv(O(2))-NIRS(resp)) with the Sv(O(2)) of blood samples. Sv(O(2))-NIRS(resp) and Sv(O(2)) of blood samples agreed well over the whole range of Sv(O(2)) considered (20-95%). The two measurements showed an average difference of 1.0% and a standard deviation of the difference of 5.8%. In the human study, we found a good agreement between Sv(O(2))-NIRS(resp) and the Sv(O(2)) values measured with the NIRS venous occlusion method. Finally, in a preliminary test involving muscle exercise, Sv(O(2))-NIRS(resp) showed an expected postexercise decrease from the initial baseline value and a subsequent recovery to baseline.
1  Bioengineering Center, Department of Electrical Engineering and Computer Science Tufts University, Medford 02155-6013; and 2  NMR Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129 We present a noninvasive method to measure the venous oxygen saturation (Sv O 2 ) in tissues using near-infrared spectroscopy (NIRS). This method is based on the respiration-induced oscillations of the near-infrared absorption in tissues, and we call it spiroximetry (the prefix spiro means respiration). We have tested this method in three piglets (hind leg) and in eight human subjects (vastus medialis and vastus lateralis muscles). In the piglet study, we compared our NIRS measurements of the Sv O 2 (Sv O 2 -NIRS resp ) with the Sv O 2 of blood samples. Sv O 2 -NIRS resp and Sv O 2 of blood samples agreed well over the whole range of Sv O 2 considered (20-95%). The two measurements showed an average difference of 1.0% and a standard deviation of the difference of 5.8%. In the human study, we found a good agreement between Sv O 2 -NIRS resp and the Sv O 2 values measured with the NIRS venous occlusion method. Finally, in a preliminary test involving muscle exercise, Sv O 2 -NIRS resp showed an expected postexercise decrease from the initial baseline value and a subsequent recovery to baseline. tissue spectroscopy; frequency-domain; pulse oximetry; hemoglobin saturation
We present a noninvasive method to measure the venous oxygen saturation (Sv(O(2))) in tissues using near-infrared spectroscopy (NIRS). This method is based on the respiration-induced oscillations of the near-infrared absorption in tissues, and we call it spiroximetry (the prefix spiro means respiration). We have tested this method in three piglets (hind leg) and in eight human subjects (vastus medialis and vastus lateralis muscles). In the piglet study, we compared our NIRS measurements of the Sv(O(2)) (Sv(O(2))-NIRS(resp)) with the Sv(O(2)) of blood samples. Sv(O(2))-NIRS(resp) and Sv(O(2)) of blood samples agreed well over the whole range of Sv(O(2)) considered (20-95%). The two measurements showed an average difference of 1.0% and a standard deviation of the difference of 5.8%. In the human study, we found a good agreement between Sv(O(2))-NIRS(resp) and the Sv(O(2)) values measured with the NIRS venous occlusion method. Finally, in a preliminary test involving muscle exercise, Sv(O(2))-NIRS(resp) showed an expected postexercise decrease from the initial baseline value and a subsequent recovery to baseline.We present a noninvasive method to measure the venous oxygen saturation (Sv(O(2))) in tissues using near-infrared spectroscopy (NIRS). This method is based on the respiration-induced oscillations of the near-infrared absorption in tissues, and we call it spiroximetry (the prefix spiro means respiration). We have tested this method in three piglets (hind leg) and in eight human subjects (vastus medialis and vastus lateralis muscles). In the piglet study, we compared our NIRS measurements of the Sv(O(2)) (Sv(O(2))-NIRS(resp)) with the Sv(O(2)) of blood samples. Sv(O(2))-NIRS(resp) and Sv(O(2)) of blood samples agreed well over the whole range of Sv(O(2)) considered (20-95%). The two measurements showed an average difference of 1.0% and a standard deviation of the difference of 5.8%. In the human study, we found a good agreement between Sv(O(2))-NIRS(resp) and the Sv(O(2)) values measured with the NIRS venous occlusion method. Finally, in a preliminary test involving muscle exercise, Sv(O(2))-NIRS(resp) showed an expected postexercise decrease from the initial baseline value and a subsequent recovery to baseline.
Author Franceschini, Maria Angela
Fantini, Sergio
Boas, David A
Lin, David W
Diamond, Solomon G
Nadgir, Shalini
Moore, John B
Zourabian, Anna
AuthorAffiliation 1 Bioengineering Center, Department of Electrical Engineering and Computer Science Tufts University, Medford 02155-6013
2 NMR Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129
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  fullname: Fantini, Sergio
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Issue 1
Keywords Human
Oxygen
Venous blood
Pulse oxymetry
Saturation
Frequency domain method
Pig
Near infrared spectrometry
Tissue
Vertebrata
Mammalia
Non invasive method
Hemoglobin
Artiodactyla
Measurement method
Ungulata
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Snippet 1  Bioengineering Center, Department of Electrical Engineering and Computer Science Tufts University, Medford 02155-6013; and 2  NMR Center, Massachusetts...
We present a noninvasive method to measure the venous oxygen saturation (Sv O 2 ) in tissues using near-infrared spectroscopy (NIRS). This method is based on...
We present a noninvasive method to measure the venous oxygen saturation (Sv(O(2))) in tissues using near-infrared spectroscopy (NIRS). This method is based on...
We present a noninvasive method to measure the venous oxygen saturation (SVo2) in tissues using near-infrared spectroscopy (NIRS). This method is based on the...
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StartPage 372
SubjectTerms Adult
Algorithms
Animals
Biological and medical sciences
Blood
Blood gas. Hemoglobin. Myoglobin. Hemotissulary gas exchange. Acid-base balance
Exercise - physiology
Female
Fundamental and applied biological sciences. Psychology
Hemoglobin
Hindlimb - blood supply
Humans
Infrared spectroscopy
Male
Oximetry - methods
Oxygen
Oxygen - blood
Regional Blood Flow - physiology
Respiration
Spectroscopy, Near-Infrared
Spectrum analysis
Spirometry - methods
Swine
Tissues
Vertebrates: respiratory system
Title Near-infrared spiroximetry: noninvasive measurements of venous saturation in piglets and human subjects
URI http://jap.physiology.org/cgi/content/abstract/92/1/372
https://www.ncbi.nlm.nih.gov/pubmed/11744680
https://www.proquest.com/docview/222227059
https://www.proquest.com/docview/71335433
https://pubmed.ncbi.nlm.nih.gov/PMC3786737
Volume 92
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