Development of a non-alcoholic steatohepatitis model with rapid accumulation of fibrosis, and its treatment using mesenchymal stem cells and their small extracellular vesicles

• Published in: Regenerative therapy Vol. 14; pp. 252 - 261
• Main Authors: Watanabe, Takayuki, Tsuchiya, Atsunori, Takeuchi, Suguru, Nojiri, Shunsuke, Yoshida, Tomoaki, Ogawa, Masahiro, Itoh, Michiko, Takamura, Masaaki, Suganami, Takayoshi, Ogawa, Yoshihiro, Terai, Shuji
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2020; Japanese Society for Regenerative Medicine; Elsevier
• Subjects: Cirrhosis; Mesenchymal stem cells; Non-alcoholic steatohepatitis; Original; Small extracellular vesicles; NAFLD; Small extracellular vesicles; T-cho; sEV; ALT; HCC; NASH; WD; MCD; MC4R; Cirrhosis; hCLS; ND; T-bil; Non-alcoholic steatohepatitis; MSC; Mesenchymal stem cells; MC4R, melanocortin-4 receptor-deficient; sEV, small extracellular vesicle; NASH, non-alcoholic steatohepatitis; hCLS, hepatic crown-like structure; T-cho, total cholesterol; MCD, methionine-choline-deficient diet; ND, normal diet; ALT, alanine transaminase; NAFLD, non-alcoholic fatty liver disease; HCC, hepatocellular carcinoma; WD, Western diet; MSC, mesenchymal stem cell; T-bil, total bilirubin

Currently, there are no approved drugs for treating non-alcoholic steatohepatitis (NASH); however, mesenchymal stem cells (MSCs) and their small extracellular vesicles (sEVs), which possess immunomodulatory activities, are potential candidates. This study aimed to develop a mouse model of NASH with...