Enhancement of cutaneous immunity during aging by blocking p38 mitogen-activated protein (MAP) kinase–induced inflammation

• Published in: Journal of allergy and clinical immunology Vol. 142; no. 3; pp. 844 - 856
• Main Authors: Vukmanovic-Stejic, Milica, Chambers, Emma S., Suárez-Fariñas, Mayte, Sandhu, Daisy, Fuentes-Duculan, Judilyn, Patel, Neil, Agius, Elaine, Lacy, Katie E., Turner, Carolin T., Larbi, Anis, Birault, Veronique, Noursadeghi, Mahdad, Mabbott, Neil A., Rustin, Malcolm H.A., Krueger, James G., Akbar, Arne N.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2018; Elsevier Limited; Mosby
• Subjects: Adult; Age; Aged; Aged, 80 and over; Aging; Aging - blood; Aging - immunology; Antigens; Antigens, Viral - immunology; Biopsy; C-reactive protein; C-Reactive Protein - analysis; CD4 antigen; CD4-Positive T-Lymphocytes - immunology; CD8 antigen; CD8-Positive T-Lymphocytes - immunology; Cell growth; Cytokines; Enzyme inhibitors; Erythema; Female; Herpesvirus 3, Human - immunology; Human subjects; Humans; Hypotheses; Immunity; Infections; Inflammation; Inflammation - blood; Inflammation - immunology; Interleukin 6; Interleukin-6 - blood; Kinases; Leukocytes; Lymphocytes T; Male; Malignancy; MAP kinase; Middle Aged; Monocytes; p38 mitogen-activated protein kinase; p38 Mitogen-Activated Protein Kinases - immunology; Peripheral blood; Protein kinase inhibitors; Proteins; Secretion; Skin; Skin - immunology; Studies; Tumor necrosis factor; Tumor Necrosis Factor-alpha - blood; Tumor necrosis factor-α; Vaccine efficacy; Varicella; varicella zoster virus; Young Adult; United Kingdom > UK; CRP; CBA; VZV; inflammation; DEG; Aging; varicella zoster virus; p38 mitogen-activated protein kinase; MAP; TRM; DC

Immunity decreases with age, which leads to reactivation of varicella zoster virus (VZV). In human subjects age-associated immune changes are usually measured in blood leukocytes; however, this might not reflect alterations in tissue-specific immunity. We used a VZV antigen challenge system in the s...