Development of Cephradine-Loaded Gelatin/Polyvinyl Alcohol Electrospun Nanofibers for Effective Diabetic Wound Healing: In-Vitro and In-Vivo Assessments

• Published in: Pharmaceutics Vol. 13; no. 3; p. 349
• Main Authors: Razzaq, Anam, Khan, Zaheer, Saeed, Aasim, Shah, Kiramat, Khan, Naveed, Menaa, Bouzid, Iqbal, Haroon, Menaa, Farid
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.03.2021; MDPI
• Subjects: Bacterial infections; Care and treatment; Cell adhesion & migration; Cephradine; Chronic illnesses; Complications and side effects; Diabetes; diabetic wound; electrospun nanofibers; Fibers; gelatin/polyvinyl alcohol; Gram-positive bacteria; Hyperglycemia; Infections; Insulin; Metabolism; Methods; Nanotechnology; Pharmaceutical industry; Polymers; Polyvinyl alcohol; Production processes; Skin; Staphylococcus aureus; Staphylococcus aureus infections; Temperature; Tissue engineering; translational medicine; Wound healing; China; United States > US; translational medicine; diabetic wound; electrospun nanofibers; cephradine; Staphylococcus aureus; gelatin/polyvinyl alcohol
• ISSN: 1999-4923; 1999-4923
• DOI: 10.3390/pharmaceutics13030349

Diabetic wound infections caused by conventional antibiotic-resistant Staphylococcus aureus strains are fast emerging, leading to life-threatening situations (e.g., high costs, morbidity, and mortality) associated with delayed healing and chronic inflammation. Electrospinning is one of the most wide...