Upregulation of intermediate calcium-activated potassium channels counterbalance the impaired endothelium-dependent vasodilation in stroke-prone spontaneously hypertensive rats

• Published in: Translational research : the journal of laboratory and clinical medicine Vol. 154; no. 4; pp. 183 - 193
• Main Authors: Giachini, Fernanda R.C., Carneiro, Fernando S., Lima, Victor V., Carneiro, Zidonia N., Dorrance, Anne, Webb, R. Clinton, Tostes, Rita C.
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.10.2009; Elsevier
• Subjects: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology; Acetylcholine - pharmacology; Animals; Biological and medical sciences; Blood Pressure - drug effects; Body Weight; Charybdotoxin - pharmacology; Endothelium, Vascular - drug effects; Endothelium, Vascular - physiology; General aspects; Indomethacin - pharmacology; Internal Medicine; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Neurology; NG-Nitroarginine Methyl Ester - pharmacology; Potassium Channels, Calcium-Activated - genetics; Potassium Channels, Calcium-Activated - physiology; Rats; Rats, Inbred SHR - genetics; Rats, Inbred SHR - physiology; Rats, Inbred WKY; Up-Regulation; Vascular diseases and vascular malformations of the nervous system; Vasodilation - drug effects; Vasodilation - physiology; NO; L-NAME; WKY; Ach; SHRSP; PGI 2; BK Ca; K Ca; PSS; REST; SK Ca; TRAM-34; E max; IK Ca; EDHF; p D 2; maximum effect elicited by the agonist; endothelium-derived hyperpolarizing factor; repressor element 1-silencing transcription factor; intermediate calcium-activated potassium channels; nitric oxide; N-nitro-L-arginine methyl ester; small calcium-activated potassium channels; prostacyclin; 1-[(2-chlorophenyl)diphenylmethyl]-1H-pyrazole; calcium-activated potassium channels; large-conductance calcium-activated potassium channels; physiologic salt solution; stroke-prone spontaneously hypertensive rat; negative logarithm of the molar concentration of agonist producing 50% of the maximum response; Wistar Kyoto; acetylcholine; Hypertension; Nervous system diseases; Stroke; Calcium; Rat; Rodentia; Cardiovascular disease; Ionic channel; Inorganic element; Vasodilation; Cerebral disorder; Endothelium; Vascular disease; Medicine; Vasomotricity; Vertebrata; Mammalia; Animal; Central nervous system disease; Clinical biology; Potassium; Cerebrovascular disease
• ISSN: 1931-5244; 1878-1810
• DOI: 10.1016/j.trsl.2009.07.003

Endothelial dysfunction has been linked to a decrease in nitric oxide (NO) bioavailability and attenuated endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxation. The small (SK Ca) and intermediate (IK Ca) calcium-activated potassium channels play a key role in endothelium-dependent re...