Cigarette whole smoke solutions disturb mucin homeostasis in a human in vitro airway tissue model

• Published in: Toxicology (Amsterdam) Vol. 409; pp. 119 - 128
• Main Authors: Cao, Xuefei, Wang, Yiying, Xiong, Rui, Muskhelishvili, Levan, Davis, Kelly, Richter, Patricia A., Heflich, Robert H.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.11.2018
• Subjects: adverse effects; Apoptosis; Cigarette whole smoke solutions (WSSs); cigarettes; Cilia beating frequency (CBF); Emergency; gene expression regulation; genes; Goblet cell hyperplasia; goblet cells; homeostasis; Human air-liquid-interface (ALI) airway tissue model; humans; hypersecretion; mucins; Mucus secretion; protocols; respiratory tract diseases; smoke; toxicity; Cilia beating frequency (CBF); Cigarette whole smoke solutions (WSSs); Goblet cell hyperplasia; Human air-liquid-interface (ALI) airway tissue model; Apoptosis; Mucus secretion

Many cigarette smoke-associated airway diseases involve alterations in mucin homeostasis. With the rationale that relevant tissue responses can be measured to evaluate the adverse health effects of tobacco products, we assessed changes in mucin secretion and the density and size of goblet cells in a...