Associations between fungal and bacterial microbiota of airways and asthma endotypes

• Published in: Journal of allergy and clinical immunology Vol. 144; no. 5; pp. 1214 - 1227.e7
• Main Authors: Sharma, Anukriti, Laxman, Bharathi, Naureckas, Edward T., Hogarth, D. Kyle, Sperling, Anne I., Solway, Julian, Ober, Carole, Gilbert, Jack A., White, Steven R.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2019; Elsevier Limited
• Subjects: 16S ribosomal RNA; airway inflammation; Alveoli; Asthma; Atopy; Bacteria; Bronchus; Corticosteroids; FEV1; Fungi; Genera; Inflammation; Leukocytes (eosinophilic); Leukocytes (neutrophilic); Library collections; Microbiota; Nitric oxide; Phenotypes; Respiratory tract; Respiratory tract diseases; Software; microbiota; airway inflammation; Feno; ABC; bacteria; GLM; ITS; PERMANOVA; WGCNA; corticosteroids; EB; CA; T2; BMI; AA; OOB; 16S ribosomal RNA; BH-FDR; ESV; NMDS; ANCOM; BAL; Asthma; ANA; fungi; PICRUSt; CNA; ICS; FEV1; OCS; FEV

The relationship between asthma, atopy, and underlying type 2 (T2) airway inflammation is complex. Although the bacterial airway microbiota is known to differ in asthmatic patients, the fungal and bacterial markers that discriminate T2-high (eosinophilic) and T2-low (neutrophilic/mixed-inflammation)...