Circulating Fetuin-A and Risk of Type 2 Diabetes: A Mendelian Randomization Analysis

• Published in: Diabetes (New York, N.Y.) Vol. 67; no. 6; pp. 1200 - 1205
• Main Authors: Kröger, Janine, Meidtner, Karina, Stefan, Norbert, Guevara, Marcela, Kerrison, Nicola D., Ardanaz, Eva, Aune, Dagfinn, Boeing, Heiner, Dorronsoro, Miren, Dow, Courtney, Fagherazzi, Guy, Franks, Paul W., Freisling, Heinz, Gunter, Marc J., Huerta, José María, Kaaks, Rudolf, Key, Timothy J., Khaw, Kay Tee, Krogh, Vittorio, Kühn, Tilman, Mancini, Francesca Romana, Mattiello, Amalia, Nilsson, Peter M., Olsen, Anja, Overvad, Kim, Palli, Domenico, Quirós, J. Ramón, Rolandsson, Olov, Sacerdote, Carlotta, Sala, Núria, Salamanca-Fernández, Elena, Sluijs, Ivonne, Spijkerman, Annemieke M.W., Tjonneland, Anne, Tsilidis, Konstantinos K., Tumino, Rosario, van der Schouw, Yvonne T., Forouhi, Nita G., Sharp, Stephen J., Langenberg, Claudia, Riboli, Elio, Schulze, Matthias B., Wareham, Nicholas J.
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.06.2018
• Subjects: Adult; Aged; alpha-2-HS-Glycoprotein - analysis; alpha-2-HS-Glycoprotein - genetics; Biomarkers - blood; Cancer; Case-Control Studies; Clinical Medicine; Cohort Studies; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - epidemiology; Endocrinology and Diabetes; Endokrinologi och diabetes; Enzyme-Linked Immunosorbent Assay; Europe - epidemiology; Female; Genetic Association Studies; Genetic diversity; Genomes; Germany - epidemiology; Humans; Immunoturbidimetry; Incidence; Insulin; Kidney diseases; Kidneys; Klinisk medicin; Male; Medical and Health Sciences; Medicin och hälsovetenskap; Mendelian Randomization Analysis; Middle Aged; Nephrology; Peritoneal dialysis; Polymorphism, Single Nucleotide; Prospective Studies; Reproducibility of Results; Risk; Secretion; Single-nucleotide polymorphism; Europe; Germany

Fetuin-A, a hepatic-origin protein, is strongly positively associated with risk of type 2 diabetes in human observational studies, but it is unknown whether this association is causal. We aimed to study the potential causal relation of circulating fetuin-A to risk of type 2 diabetes in a Mendelian r...