Notch signaling triggered via the ligand DLL4 impedes M2 macrophage differentiation and promotes their apoptosis - Pagie, Sylvain; Gérard, Nathalie; Charreau, Béatrice (Cell communication and signaling, 2018)
Keywords: Apoptosis; Apoptosis - drug effects; bcl-2-Associated X Protein - metabolism; BH3 Interacting Domain Death Agonist Protein - metabolism; Cell differentiation; Cell Differentiation - drug effects; Cells, Cultured; DLL4; Gene expression; Humans; Il-4; Immunology; Intercellular Signaling Peptides and Proteins - chemistry; Intercellular Signaling Peptides and Proteins - genetics; Intercellular Signaling Peptides and Proteins - metabolism; Interferon-gamma - pharmacology; Interleukin-4 - pharmacology; Janus Kinases - metabolism; Life Sciences; Ligands; Lipopolysaccharides - pharmacology; M2 macrophage; Macrophage; Macrophages; Macrophages - cytology; Macrophages - drug effects; Macrophages - metabolism; Monocytes - cytology; Monocytes - metabolism; Notch pathway; Notch1; Receptors, Notch - metabolism; Recombinant Proteins - biosynthesis; Recombinant Proteins - pharmacology; Signal Transduction - drug effects; STAT Transcription Factors - metabolism; DLL4; Polarization; M2 macrophage; Notch pathway; Notch1; Il-4; JAK/stat; Apoptosis; Macrophage; Team4; CRTI