Alteration of Venous Drainage Route in Idiopathic Normal Pressure Hydrocephalus and Normal Aging
Idiopathic normal pressure hydrocephalus (iNPH) is a highly prevalent condition in the elderly population; however, the underlying pathophysiology in relation to the aging process remains unclear. To investigate the effect of removal of cerebrospinal fluid by lumbar "tap test" on the cereb...
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| Published in | Frontiers in aging neuroscience Vol. 9; p. 387 |
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| Main Authors | , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
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Frontiers Research Foundation
23.11.2017
Frontiers Media S.A |
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| Online Access | Get full text |
| ISSN | 1663-4365 1663-4365 |
| DOI | 10.3389/fnagi.2017.00387 |
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| Abstract | Idiopathic normal pressure hydrocephalus (iNPH) is a highly prevalent condition in the elderly population; however, the underlying pathophysiology in relation to the aging process remains unclear. To investigate the effect of removal of cerebrospinal fluid by lumbar "tap test" on the cerebral circulation in patients with iNPH, 14 patients with "probable" iNPH were studied using a novel blood tracking technique based on blood oxygenation level-dependent (BOLD) magnetic resonance signal intensity. By tracking the propagation of the low-frequency component of the BOLD signal, extended venous drainage times were observed in the periventricular region of the patients, which was reversed by tap test. Interestingly, the venous drainage time in the periventricular region exhibited an age-related prolongation in the healthy control group. Additional regression analyses involving 81 control subjects revealed a dissociation of deep and superficial venous systems with increasing age, presumably reflecting focal inefficiency in the deep system. Our results not only provide insights into the etiology of iNPH, but also point to a potential non-invasive biomarker for screening iNPH. |
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| AbstractList | Idiopathic normal pressure hydrocephalus (iNPH) is a highly prevalent condition in the elderly population; however, the underlying pathophysiology in relation to the aging process remains unclear. To investigate the effect of removal of cerebrospinal fluid by lumbar “tap test” on the cerebral circulation in patients with iNPH, 14 patients with “probable” iNPH were studied using a novel blood tracking technique based on blood oxygenation level-dependent (BOLD) magnetic resonance signal intensity. By tracking the propagation of the low-frequency component of the BOLD signal, extended venous drainage times were observed in the periventricular region of the patients, which was reversed by tap test. Interestingly, the venous drainage time in the periventricular region exhibited an age-related prolongation in the healthy control group. Additional regression analyses involving 81 control subjects revealed a dissociation of deep and superficial venous systems with increasing age, presumably reflecting focal inefficiency in the deep system. Our results not only provide insights into the etiology of iNPH, but also point to a potential non-invasive biomarker for screening iNPH. Idiopathic normal pressure hydrocephalus (iNPH) is a highly prevalent condition in the elderly population; however, the underlying pathophysiology in relation to the aging process remains unclear. To investigate the effect of removal of cerebrospinal fluid by lumbar "tap test" on the cerebral circulation in patients with iNPH, 14 patients with "probable" iNPH were studied using a novel blood tracking technique based on blood oxygenation level-dependent (BOLD) magnetic resonance signal intensity. By tracking the propagation of the low-frequency component of the BOLD signal, extended venous drainage times were observed in the periventricular region of the patients, which was reversed by tap test. Interestingly, the venous drainage time in the periventricular region exhibited an age-related prolongation in the healthy control group. Additional regression analyses involving 81 control subjects revealed a dissociation of deep and superficial venous systems with increasing age, presumably reflecting focal inefficiency in the deep system. Our results not only provide insights into the etiology of iNPH, but also point to a potential non-invasive biomarker for screening iNPH.Idiopathic normal pressure hydrocephalus (iNPH) is a highly prevalent condition in the elderly population; however, the underlying pathophysiology in relation to the aging process remains unclear. To investigate the effect of removal of cerebrospinal fluid by lumbar "tap test" on the cerebral circulation in patients with iNPH, 14 patients with "probable" iNPH were studied using a novel blood tracking technique based on blood oxygenation level-dependent (BOLD) magnetic resonance signal intensity. By tracking the propagation of the low-frequency component of the BOLD signal, extended venous drainage times were observed in the periventricular region of the patients, which was reversed by tap test. Interestingly, the venous drainage time in the periventricular region exhibited an age-related prolongation in the healthy control group. Additional regression analyses involving 81 control subjects revealed a dissociation of deep and superficial venous systems with increasing age, presumably reflecting focal inefficiency in the deep system. Our results not only provide insights into the etiology of iNPH, but also point to a potential non-invasive biomarker for screening iNPH. Idiopathic normal pressure hydrocephalus (iNPH) is a highly prevalent condition in the elderly population; however, the underlying pathophysiology in relation to the aging process remains unclear. To investigate the effect of removal of cerebrospinal fluid by lumbar “tap test” on the cerebral circulation in iNPH patients, 14 “probable” iNPH patients were studied using a novel blood tracking technique based on blood oxygenation level-dependent (BOLD) magnetic resonance signal intensity. By tracking the propagation of the low-frequency component of the BOLD signal, extended venous drainage times were observed in the periventricular region of iNPH patients, which was reversed by tap test. Interestingly, the venous drainage time in the periventricular region exhibited an age-related prolongation in the healthy control group. Additional regression analysis involving 81 control subjects revealed a dissociation of deep and superficial venous systems with increasing age, presumably reflecting focal inefficiency in the deep system. The overall results not only provide a clue to the etiology, but also suggest a possible noninvasive biomarker for screening iNPH. |
| Author | Yoshida, Kazumichi Murai, Toshiya Odagiri, Masashi Nishida, Sei Nakagami, Yukako Satow, Takeshi Kikuchi, Takayuki Aso, Toshihiko Ueda, Keita Fukuyama, Hidenao Kunieda, Takeharu Komuro, Taro Ueno, Tsukasa Oishi, Naoya Miyamoto, Susumu |
| AuthorAffiliation | 3 Department of Neurosurgery, Kyoto University Graduate School of Medicine , Kyoto , Japan 5 Faculty of Health Care Science, Kyoto Tachibana University , Kyoto , Japan 4 Department of Psychiatry, Graduate School of Medicine, Kyoto University , Kyoto , Japan 6 Department of Neurosurgery, Graduate School of Medicine, Ehime University , Matsuyama , Japan 1 Department of Neurosurgery, Nagahama City Hospital , Nagahama , Japan 2 Human Brain Research Center, Kyoto University Graduate School of Medicine , Kyoto , Japan |
| AuthorAffiliation_xml | – name: 2 Human Brain Research Center, Kyoto University Graduate School of Medicine , Kyoto , Japan – name: 5 Faculty of Health Care Science, Kyoto Tachibana University , Kyoto , Japan – name: 3 Department of Neurosurgery, Kyoto University Graduate School of Medicine , Kyoto , Japan – name: 1 Department of Neurosurgery, Nagahama City Hospital , Nagahama , Japan – name: 4 Department of Psychiatry, Graduate School of Medicine, Kyoto University , Kyoto , Japan – name: 6 Department of Neurosurgery, Graduate School of Medicine, Ehime University , Matsuyama , Japan |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29218007$$D View this record in MEDLINE/PubMed |
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| Copyright | 2017. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © 2017 Satow, Aso, Nishida, Komuro, Ueno, Oishi, Nakagami, Odagiri, Kikuchi, Yoshida, Ueda, Kunieda, Murai, Miyamoto and Fukuyama. 2017 Satow, Aso, Nishida, Komuro, Ueno, Oishi, Nakagami, Odagiri, Kikuchi, Yoshida, Ueda, Kunieda, Murai, Miyamoto and Fukuyama |
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| Keywords | normal aging cerebral blood flow low-frequency oscillation in systemic circulation normal pressure hydrocephalus BOLD signal cerebral venous drainage |
| Language | English |
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| SubjectTerms | Aging BOLD signal Cerebral blood flow cerebral venous drainage Cerebrospinal fluid Etiology Functional magnetic resonance imaging Geriatrics Hydrocephalus low-frequency oscillation in systemic circulation Magnetic resonance imaging Neuroscience normal aging normal pressure hydrocephalus Older people Patients Pressure Wound drainage |
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| Title | Alteration of Venous Drainage Route in Idiopathic Normal Pressure Hydrocephalus and Normal Aging |
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