Left ventricular outflow obstruction predicts increase in systolic pressure gradients and blood residence time after transcatheter mitral valve replacement

• Published in: Scientific reports Vol. 8; no. 1; pp. 15540 - 11
• Main Authors: De Vecchi, Adelaide, Marlevi, David, Nordsletten, David A., Ntalas, Ioannis, Leipsic, Jonathon, Bapat, Vinayak, Rajani, Ronak, Niederer, Steven A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.10.2018; Nature Publishing Group
• Subjects: 59; 631/114/2397; 631/443/592/75/591; Aged; Aged, 80 and over; Blood Pressure; Cardiac Catheterization - methods; Catheters; Computer applications; Computer Simulation; Data processing; Decision making; Female; Heart diseases; Heart Valve Prosthesis Implantation - methods; Hemodynamics; Humanities and Social Sciences; Humans; Male; Mathematical models; Medicin och hälsovetenskap; Middle Aged; Mitral valve; Mitral Valve - surgery; multidisciplinary; Science; Science (multidisciplinary); Simulation; Ventricle; Ventricular Outflow Obstruction; Left Ventricular Outflow Tract (LVOT); Blood Residence Time; LVOT Obstruction; Transcatheter Mitral Valve Replacement (TMVR); Systolic Pressure Gradient

Left ventricular outflow tract (LVOT) obstruction is a relatively common consequence of transcatheter mitral valve replacement (TMVR). Although LVOT obstruction is associated with heart failure and adverse remodelling, its effects upon left ventricular hemodynamics remain poorly characterised. This...