Reporter gene imaging of protein–protein interactions in living subjects
In the past few years there has been a veritable explosion in the field of reporter gene imaging, with the aim of determining the location, duration and extent of gene expression within living subjects. An important application of this approach is the molecular imaging of interacting protein partner...
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| Published in | Current opinion in biotechnology Vol. 18; no. 1; pp. 31 - 37 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.02.2007
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| Subjects | |
| Online Access | Get full text |
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| Abstract | In the past few years there has been a veritable explosion in the field of reporter gene imaging, with the aim of determining the location, duration and extent of gene expression within living subjects. An important application of this approach is the molecular imaging of interacting protein partners, which could pave the way to functional proteomics in living animals and might provide a tool for the whole-body evaluation of new pharmaceuticals targeted to modulate protein–protein interactions. Three general methods are currently available for imaging protein–protein interactions in living subjects using reporter genes: a modified mammalian two-hybrid system, a bioluminescence resonance energy transfer (BRET) system, and split reporter protein complementation and reconstitution strategies. In the future, these innovative approaches are likely to enhance our appreciation of entire biological pathway systems and their pharmacological regulation. |
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| AbstractList | In the past few years there has been a veritable explosion in the field of reporter gene imaging, with the aim of determining the location, duration and extent of gene expression within living subjects. An important application of this approach is the molecular imaging of interacting protein partners, which could pave the way to functional proteomics in living animals and might provide a tool for the whole-body evaluation of new pharmaceuticals targeted to modulate protein–protein interactions. Three general methods are currently available for imaging protein–protein interactions in living subjects using reporter genes: a modified mammalian two-hybrid system, a bioluminescence resonance energy transfer (BRET) system, and split reporter protein complementation and reconstitution strategies. In the future, these innovative approaches are likely to enhance our appreciation of entire biological pathway systems and their pharmacological regulation. In the past few years there has been a veritable explosion in the field of reporter gene imaging, with the aim of determining the location, duration and extent of gene expression within living subjects. An important application of this approach is the molecular imaging of interacting protein partners, which could pave the way to functional proteomics in living animals and might provide a tool for the whole-body evaluation of new pharmaceuticals targeted to modulate protein-protein interactions. Three general methods are currently available for imaging protein-protein interactions in living subjects using reporter genes: a modified mammalian two-hybrid system, a bioluminescence resonance energy transfer (BRET) system, and split reporter protein complementation and reconstitution strategies. In the future, these innovative approaches are likely to enhance our appreciation of entire biological pathway systems and their pharmacological regulation.In the past few years there has been a veritable explosion in the field of reporter gene imaging, with the aim of determining the location, duration and extent of gene expression within living subjects. An important application of this approach is the molecular imaging of interacting protein partners, which could pave the way to functional proteomics in living animals and might provide a tool for the whole-body evaluation of new pharmaceuticals targeted to modulate protein-protein interactions. Three general methods are currently available for imaging protein-protein interactions in living subjects using reporter genes: a modified mammalian two-hybrid system, a bioluminescence resonance energy transfer (BRET) system, and split reporter protein complementation and reconstitution strategies. In the future, these innovative approaches are likely to enhance our appreciation of entire biological pathway systems and their pharmacological regulation. In the past few years there has been a veritable explosion in the field of reporter gene imaging, with the aim of determining the location, duration and extent of gene expression within living subjects. An important application of this approach is the molecular imaging of interacting protein partners, which could pave the way to functional proteomics in living animals and might provide a tool for the whole-body evaluation of new pharmaceuticals targeted to modulate proteinprotein interactions. Three general methods are currently available for imaging proteinprotein interactions in living subjects using reporter genes: a modified mammalian two-hybrid system, a bioluminescence resonance energy transfer (BRET) system, and split reporter protein complementation and reconstitution strategies. In the future, these innovative approaches are likely to enhance our appreciation of entire biological pathway systems and their pharmacological regulation. |
| Author | Massoud, Tarik F Ray, Pritha De, Abhijit Gambhir, Sanjiv S Paulmurugan, Ramasamy |
| AuthorAffiliation | 3 Departments of Radiology and Bioengineering, Bio-X Program, Stanford University School of Medicine, James H Clark Center, 318 Campus Drive, East Wing, Stanford, California 94305-5427, USA 2 Molecular Imaging Program at Stanford (MIPS), Bio-X Program, Stanford University School of Medicine, James H Clark Center, 318 Campus Drive, Stanford, CA 94305, USA 1 Department of Radiology, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK |
| AuthorAffiliation_xml | – name: 1 Department of Radiology, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK – name: 2 Molecular Imaging Program at Stanford (MIPS), Bio-X Program, Stanford University School of Medicine, James H Clark Center, 318 Campus Drive, Stanford, CA 94305, USA – name: 3 Departments of Radiology and Bioengineering, Bio-X Program, Stanford University School of Medicine, James H Clark Center, 318 Campus Drive, East Wing, Stanford, California 94305-5427, USA |
| Author_xml | – sequence: 1 givenname: Tarik F surname: Massoud fullname: Massoud, Tarik F email: tfm23@radiol.cam.ac.uk organization: Department of Radiology, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK – sequence: 2 givenname: Ramasamy surname: Paulmurugan fullname: Paulmurugan, Ramasamy organization: Molecular Imaging Program at Stanford (MIPS), Bio-X Program, Stanford University School of Medicine, James H Clark Center, 318 Campus Drive, Stanford, CA 94305, USA – sequence: 3 givenname: Abhijit surname: De fullname: De, Abhijit organization: Molecular Imaging Program at Stanford (MIPS), Bio-X Program, Stanford University School of Medicine, James H Clark Center, 318 Campus Drive, Stanford, CA 94305, USA – sequence: 4 givenname: Pritha surname: Ray fullname: Ray, Pritha organization: Molecular Imaging Program at Stanford (MIPS), Bio-X Program, Stanford University School of Medicine, James H Clark Center, 318 Campus Drive, Stanford, CA 94305, USA – sequence: 5 givenname: Sanjiv S surname: Gambhir fullname: Gambhir, Sanjiv S organization: Molecular Imaging Program at Stanford (MIPS), Bio-X Program, Stanford University School of Medicine, James H Clark Center, 318 Campus Drive, Stanford, CA 94305, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17254764$$D View this record in MEDLINE/PubMed |
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| Title | Reporter gene imaging of protein–protein interactions in living subjects |
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