Mucosal bromodomain-containing protein 4 mediates aeroallergen-induced inflammation and remodeling - Tian, Bing; Hosoki, Koa; Liu, Zhiqing; Yang, Jun; Zhao, Yingxin; Sun, Hong; Zhou, Jia; Rytting, Erik; Kaphalia, Lata; Calhoun, William J.; Sur, Sanjiv; Brasier, Allan R. (Journal of allergy and clinical immunology, 2019)
Keywords: aeroallergen; airway remodeling; Airway Remodeling - immunology; Allergens; Allergies; Animals; Antigens; Asthma; Asthma - immunology; Asthma - metabolism; Asthma - pathology; Biopsy; Bromodomain-containing protein 4; Cats; Cell Cycle Proteins - metabolism; Chromatin; Collagen; Dander; Dander - immunology; DNA-directed RNA polymerase; epigenetics; Epithelial cells; Epithelial-Mesenchymal Transition - immunology; Experiments; Extracellular matrix; Fibrosis; Gene expression; Histone acetyltransferase; histone acetyltransferase activity; Human subjects; Humans; Hypersensitivity - immunology; Hypersensitivity - metabolism; Hypersensitivity - pathology; Immunofluorescence; Immunoglobulin E; Inflammation; Inflammation - immunology; Inflammation - metabolism; Inflammation - pathology; Kinases; Laboratories; Lungs; Mesenchyme; Mice; Mice, Inbred C57BL; Morbidity; Mucosa; myofibroblast; NF-κB protein; nuclear factor κB; Nuclear Proteins - metabolism; Peptides; Polymerase chain reaction; Proteins; RelA protein; Respiratory function; Respiratory Mucosa - immunology; Respiratory Mucosa - metabolism; Respiratory Mucosa - pathology; Respiratory tract; Respiratory tract diseases; RNA polymerase; Signal transduction; Transcription Factors - metabolism; BD; IKKi; nuclear factor κB; PAS; H3K122Ac; PLA; myofibroblast; CDE; COL1A; RNA Pol II; epigenetics; aeroallergen; SRM; histone acetyltransferase activity; NF-κB; α-SMA; UTMB; shRNA; TLR; WT; BRD4; Bromodomain-containing protein 4; IFCM; MS; rCDE; airway remodeling; BALF; qRT-PCR; FN1; IKK; BMS; DAPI; EMT; ECM; MMP