Using the Influenza Patient-reported Outcome (FLU-PRO) diary to evaluate symptoms of influenza viral infection in a healthy human challenge model

• Published in: BMC infectious diseases Vol. 18; no. 1; pp. 353 - 9
• Main Authors: Han, Alison, Poon, Jiat-Ling, Powers, John H., Leidy, Nancy K., Yu, Ren, Memoli, Matthew J.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 28.07.2018; BioMed Central; BMC
• Subjects: Adolescent; Adult; Analysis; Economic aspects; Female; Health care costs; Healthy Volunteers; Hospitalization; Human challenge study; Human Experimentation; Humans; Influenza; Influenza A virus - physiology; Influenza, Human - diagnosis; Influenza, Human - pathology; Influenza, Human - virology; Male; Medical Records; Models, Biological; Orthomyxoviridae - physiology; Patient outcomes; Patient Reported Outcome Measures; Surveys and Questionnaires; Symptoms; Virus; Virus Shedding; Young Adult; United States; Virus; Human challenge study; Influenza; Symptoms

In clinical studies involving a healthy volunteer human challenge model, a valid and reliable measure to assess the evolution of patient-reported symptom type and severity following viral exposure is necessary. This study examines the use of the InFLUenza Patient-Reported Outcome (FLU-PRO) diary as...